The effect of esketamine on perioperative anxiety and depressive symptoms in patients undergoing total hysterectomy

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-05-08 DOI:10.1111/jog.16311

Jinfeng Ding, Yanqing Yang, Donghang Cao, Tingting Wang, Qimin Yu

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引用次数: 0

Abstract

Aim

This study aimed to evaluate the effect of esketamine on perioperative anxiety and depressive symptoms, acute stress reaction, and serum neurotransmitters in patients undergoing total hysterectomy.

Methods

Clinical data of 120 patients undergoing total hysterectomy from May 2020 to June 2021 were retrospectively analyzed and divided into group C (3 mL of saline administered intravenously 10 min before surgical excision, 65 patients) or group K (0.5 mg/kg of esketamine administered intravenously 10 min before surgical excision, 55 patients).

Results

Acute stress reaction, depression, and anxiety; and myeloperoxidase levels were lower while serum dopamine, 5-hydroxytryptamine, neuropeptide, as well as brain-derived neurotrophic factor levels were higher in group K than those in group C at 12 h postoperatively (p < 0.05). Additionally, analgesic effect and postoperative fatigue at 3 h and 12 h postoperatively were lower in group K than those in group C (p < 0.05). The incidence of adverse reactions in group K (14.55%) did not differ significantly from group C (4.62%) (p > 0.05).

Conclusions

In summary, as a preventive measure for patients undergoing total hysterectomy, esketamine can reduce perioperative anxiety and depression, result in good analgesic and sedative effects without significantly increasing adverse effects.

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艾氯胺酮对全子宫切除术患者围手术期焦虑和抑郁症状的影响

目的探讨艾氯胺酮对全子宫切除术患者围术期焦虑抑郁症状、急性应激反应及血清神经递质的影响。方法回顾性分析2020年5月至2021年6月120例全子宫切除术患者的临床资料，分为C组（术前10 min静脉给予生理盐水3ml， 65例）和K组（术前10 min静脉给予艾氯胺酮0.5 mg/kg， 55例）。结果急性应激反应、抑郁、焦虑；K组术后12 h血清多巴胺、5-羟色胺、神经肽、脑源性神经营养因子水平均高于C组（p < 0.05）。K组术后3 h、12 h的镇痛效果及术后疲劳均低于C组（p < 0.05）。K组不良反应发生率（14.55%）与C组（4.62%）差异无统计学意义（p > 0.05）。结论综上所述，艾氯胺酮作为全子宫切除术患者的预防措施，可减少围手术期的焦虑和抑郁情绪，达到良好的镇痛镇静效果，且不良反应未明显增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.