{"title":"Uncrossed Cerebellar Diaschisis in Hemimegalencephaly: Evaluated by FDG-PET and Diffusion Tensor Tractography","authors":"Risa Kagaya, Hiroyuki Maki, Hiroshi Matsuda, Hirohito Kan, Yukio Kimura, Yoko Shigemoto, Tomoki Imokawa, Keiya Iijima, Masaki Iwasaki, Eiji Nakagawa, Noriko Sato","doi":"10.1002/jdn.70022","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>This study aimed to assess cerebrocerebellar connectivity in patients with hemimegalencephaly (HME) using <sup>18</sup>F-fluorodeoxyglucose positron emission tomography (FDG-PET) and diffusion tensor imaging (DTI), as uncrossed cerebellar diaschisis is often observed in patients with HME.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Thirty-one patients with HME underwent FDG-PET and magnetic resonance imaging. Cerebellar and cerebral cortical uptake was measured using FDG-PET, and the cerebellar diaschisis index was calculated. Fractional anisotropy (FA) values for crossed and uncrossed cortico-ponto-cerebellar (CPC) fibres were obtained via DTI. Correlation between the cerebellar diaschisis index and FA values, seizure onset, frequency and developmental quotient scores were analysed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Uncrossed cerebellar diaschisis was present in 68% of patients, whereas crossed diaschisis was identified in 32% of patients. A significant positive correlation was found between the cerebellar diaschisis index and the FA values of uncrossed CPC fibres on HME and contralateral sides. No significant correlation was noted between the index and the FA values of crossed CPC fibres or clinical outcomes.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Uncrossed CPC fibres play a more significant role in cerebrocerebellar connectivity in the HME than crossed fibres. Our results provide valuable insights into the neural fibre development in HME.</p>\n </section>\n </div>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"85 3","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70022","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
This study aimed to assess cerebrocerebellar connectivity in patients with hemimegalencephaly (HME) using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and diffusion tensor imaging (DTI), as uncrossed cerebellar diaschisis is often observed in patients with HME.
Methods
Thirty-one patients with HME underwent FDG-PET and magnetic resonance imaging. Cerebellar and cerebral cortical uptake was measured using FDG-PET, and the cerebellar diaschisis index was calculated. Fractional anisotropy (FA) values for crossed and uncrossed cortico-ponto-cerebellar (CPC) fibres were obtained via DTI. Correlation between the cerebellar diaschisis index and FA values, seizure onset, frequency and developmental quotient scores were analysed.
Results
Uncrossed cerebellar diaschisis was present in 68% of patients, whereas crossed diaschisis was identified in 32% of patients. A significant positive correlation was found between the cerebellar diaschisis index and the FA values of uncrossed CPC fibres on HME and contralateral sides. No significant correlation was noted between the index and the FA values of crossed CPC fibres or clinical outcomes.
Conclusion
Uncrossed CPC fibres play a more significant role in cerebrocerebellar connectivity in the HME than crossed fibres. Our results provide valuable insights into the neural fibre development in HME.
期刊介绍：
International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.
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