Electropolymerized Molecularly Imprinted Poly(L-Phenylalanine) Modified Lab-Made Screen-Printed Carbon Electrode for Voltammetric Analysis of Acetaminophen

IF 2.7 3区化学 Q2 CHEMISTRY, ANALYTICAL

Electroanalysis Pub Date : 2025-05-09 DOI:10.1002/elan.12047

Maria Paula Campestrini Féo, Thaynara Dannehl Hoppe, Daniela Brondani

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Abstract

A selective molecularly imprinted polymer (MIP) sensor was constructed on a lab-made screen-printed carbon electrode (SPCE) for the electrochemical determination of acetaminophen (AP). Different conductive carbon inks have been investigated for SPCE production. The sensor was prepared by direct electropolymerization of the L-phenylalanine on bare SPCE in the presence of the template molecule (AP). Physicochemical and morphological characterization studies of the sensor preparation steps were performed, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), conductivity, contact angle, electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). Under optimized experimental conditions, the differential pulse voltammetry (DPV) response was linearly proportional to the AP concentration between 0.2 and 100 μmol L⁻¹ with a limit of detection (LOD) of 30 nmol L⁻¹. The MIP sensor showed good analytical performance, selectivity, and stability. Also, it was successfully used to quantify AP in fortified water samples.

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电聚合分子印迹聚（l -苯丙氨酸）修饰实验室制作的网印碳电极用于对乙酰氨基酚的伏安分析

在实验室自制的丝网印刷碳电极（SPCE）上构建了选择性分子印迹聚合物（MIP）传感器，用于对乙酰氨基酚（AP）的电化学测定。研究了不同的导电碳墨水用于SPCE的生产。在模板分子（AP）存在下，l -苯丙氨酸在裸SPCE上直接电聚合制备传感器。通过扫描电镜（SEM）、傅里叶变换红外光谱（FTIR）、电导率、接触角、电化学阻抗谱（EIS）和循环伏安法（CV）对传感器制备步骤进行了物理化学和形态表征研究。在优化的实验条件下，AP浓度在0.2 ~ 100 μmol L−1范围内与差分脉冲伏安法（DPV）响应呈线性关系，检测限为30 nmol L−1。该传感器具有良好的分析性能、选择性和稳定性。此外，该方法还成功地用于定量强化水样中的AP。

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来源期刊

Electroanalysis 化学-电化学

CiteScore

6.00

自引率

3.30%

发文量

222

审稿时长

2.4 months

期刊介绍： Electroanalysis is an international, peer-reviewed journal covering all branches of electroanalytical chemistry, including both fundamental and application papers as well as reviews dealing with new electrochemical sensors and biosensors, nanobioelectronics devices, analytical voltammetry, potentiometry, new electrochemical detection schemes based on novel nanomaterials, fuel cells and biofuel cells, and important practical applications. Serving as a vital communication link between the research labs and the field, Electroanalysis helps you to quickly adapt the latest innovations into practical clinical, environmental, food analysis, industrial and energy-related applications. Electroanalysis provides the most comprehensive coverage of the field and is the number one source for information on electroanalytical chemistry, electrochemical sensors and biosensors and fuel/biofuel cells.