A multi-channel implantable micro-magnetic stimulator for synergistic magnetic neuromodulation

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-05-05 DOI:10.1016/j.brainres.2025.149679

Lei Dong , Yenan Qi , Mengying Luan , Qiwen Liu , Meng Wang , Chunxiao Tian , Yu Zheng

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引用次数: 0

Abstract

Micro-magnetic stimulation (μMS) is an emerging technology in magnetic neuromodulation. However, for larger brain structures with complex neural pathways, such as deep brain neural clusters, traditional implantable single-point μMS devices are immobile and incapable of multi-regional magnetic modulation. While multi-channel μMS can effectively address this limitation, its large size, difficulty in implantation, and unclear synergistic modulation patterns restrict its application. To tackle these challenges, this study designs a 4 × 4 array micro-coil structure targeted at the deep hippocampal region of the mouse brain. Numerical simulations were performed to analyze the coupling coefficients among the micro-coils and the distribution of the electromagnetic field in the structure, indicating that, with optimized parameters, the effective magnetic stimulation threshold can be achieved. Based on this, a multi-channel μMS device was fabricated, solving key issues such as waterproofing, biocompatibility, and dual-brain-region implantation of both stimulation and recording electrodes. A multi-point synergistic magnetic stimulation protocol was developed. After determining the synergistic magnetic stimulation parameters and effective target positions through in vitro experiments, real-time monitoring of calcium signal changes in the CA1 region of the hippocampus in mice during synergistic magnetic stimulation was performed. The results demonstrate that synergistic magnetic stimulation significantly enhances synaptic plasticity and calcium signal activity. This validates the feasibility of the implantable multi-channel micro-magnetic stimulator.

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一种用于协同磁神经调节的多通道植入式微磁刺激器

微磁刺激（μMS）是一种新兴的磁神经调节技术。然而，对于具有复杂神经通路的大型脑结构，如深层脑神经簇，传统的植入式单点μMS器件具有不可移动性和多区域磁调制能力。虽然多通道μMS可以有效地解决这一限制，但其体积大、植入困难和不明确的协同调制模式限制了其应用。为了解决这些问题，本研究设计了一种针对小鼠大脑深部海马区的4 × 4阵列微线圈结构。通过数值模拟分析了微线圈之间的耦合系数和结构中的电磁场分布，结果表明，优化后的参数可以达到有效的磁刺激阈值。在此基础上，制备了多通道μMS器件，解决了刺激电极和记录电极的防水、生物相容性、双脑区植入等关键问题。开发了多点协同磁刺激方案。通过体外实验确定协同磁刺激参数和有效靶位后，实时监测协同磁刺激小鼠海马CA1区钙信号的变化。结果表明，协同磁刺激可显著提高突触可塑性和钙信号活性。验证了可植入多通道微磁刺激器的可行性。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.