Trends in small-molecule probes for lipid droplets

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-05-07 DOI:10.1016/j.trac.2025.118287

Yaochen Tu , Wenjie Zhang , Jiaqian Yan , Miaomiao Wang , Bubin Xu , Yusheng Xie

引用次数: 0

Abstract

Lipid droplets (LDs) are highly dynamic organelles, which are present in most eukaryotic and some prokaryotic cells. It has been long known that lipid droplets play crucial roles in lipid metabolism, membrane biosynthesis, cellular energy balance, and signaling pathways, etc. Dysfunction of LDs has been associated with many diseases, such as obesity, non-alcoholic fatty liver disease, atherosclerosis, and cancer. In recent years, small-molecule probes have become instrumental in inquiring the dynamics of LDs and targeted therapies. Herein, we describe recent key advances of LD-targeted chemical probes for studying organelle interactions, super-resolution imaging, and their application in diseases (2021–2024). We further discuss the potential of LD-targeted photodynamic photosensitizers and degraders for disease treatment. Next, we discuss the general design principles and challenges of current small-molecule probes. Finally, we recommend future research directions of LDs from our perspectives.

Abstract Image

查看原文本刊更多论文

脂滴小分子探针的发展趋势

脂滴是一种高度动态的细胞器，存在于大多数真核细胞和一些原核细胞中。脂滴在脂质代谢、膜生物合成、细胞能量平衡、信号通路等方面起着至关重要的作用。脂肪肝功能障碍与许多疾病有关，如肥胖、非酒精性脂肪肝、动脉粥样硬化和癌症。近年来，小分子探针已成为探究ld动力学和靶向治疗的工具。在此，我们描述了用于研究细胞器相互作用、超分辨率成像及其在疾病中的应用的ld靶向化学探针的最新关键进展（2021-2024）。我们进一步讨论了ld靶向光动力光敏剂和降解剂在疾病治疗中的潜力。接下来，我们讨论了当前小分子探针的一般设计原则和挑战。最后，我们从我们的角度提出了ld未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.