Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers

Q4 Neuroscience
Josiah B. Lewis , Melanie E. Fields , Michael M. Binkley , Anita Zhou , Amy Mirro , Amy Ouyang , Niket Gupta , Yasheng Chen , Slim Fellah , Alyssa E. Smith , Igor Dedkov , Monica L. Hulbert , Andria L. Ford , Hongyu An , Jin-Moo Lee , Manu S. Goyal , Kristin P. Guilliams
{"title":"Cerebral arterial lumens are enlarged in children and young adults with sickle cell disease compared to peers","authors":"Josiah B. Lewis ,&nbsp;Melanie E. Fields ,&nbsp;Michael M. Binkley ,&nbsp;Anita Zhou ,&nbsp;Amy Mirro ,&nbsp;Amy Ouyang ,&nbsp;Niket Gupta ,&nbsp;Yasheng Chen ,&nbsp;Slim Fellah ,&nbsp;Alyssa E. Smith ,&nbsp;Igor Dedkov ,&nbsp;Monica L. Hulbert ,&nbsp;Andria L. Ford ,&nbsp;Hongyu An ,&nbsp;Jin-Moo Lee ,&nbsp;Manu S. Goyal ,&nbsp;Kristin P. Guilliams","doi":"10.1016/j.ynirp.2025.100265","DOIUrl":null,"url":null,"abstract":"<div><div>Children with sickle cell disease (SCD) may develop large vessel narrowing, but studies suggest vessels may also be enlarged, possibly related to increased cerebral blood flow (CBF). We used MRI to investigate whether the cross-sectional total inflow vessel luminal area (TIVLA) proximal to the circle of Willis (carotid arteries + basilar artery) would be increased in SCD compared to age- and sex-matched peers after adjusting for CBF. Across 36 children with SCD (19 female, median age 10.7 [8.0–14.5] years and 43 controls (26 female, median age 12.7 [9.2–18.2] years) matched by age (<em>p</em> = 0.13) and sex (<em>p</em> = 0.50), the median TIVLA in the SCD group (35.9 mm<sup>2</sup> [30.7, 39.5]) was larger than controls (30.5 mm<sup>2</sup> [27.8, 35.4], <em>p</em> = 0.002). In a mixed model including age, sex, hemoglobin, CBF, SCD status, and an interaction between hemoglobin and SCD status, CBF (β = 0.11, CI 0.02–0.20, <em>p</em> = 0.02), SCD (β = 28.02, CI 5.62–50.42, <em>p</em> = 0.015), and the interaction between SCD and hemoglobin (β = −2.48, CI −4.49 to −0.47, <em>p</em> = 0.018) were all significantly associated with increased TIVLA. Notably, TIVLA as a measure of arterial lumens is larger in children with SCD, even after adjusting for CBF in the mixed model. This implies disease-specific normative values may be needed to detect early vasculopathy.</div></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"5 2","pages":"Article 100265"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimage. Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666956025000339","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}
引用次数: 0

Abstract

Children with sickle cell disease (SCD) may develop large vessel narrowing, but studies suggest vessels may also be enlarged, possibly related to increased cerebral blood flow (CBF). We used MRI to investigate whether the cross-sectional total inflow vessel luminal area (TIVLA) proximal to the circle of Willis (carotid arteries + basilar artery) would be increased in SCD compared to age- and sex-matched peers after adjusting for CBF. Across 36 children with SCD (19 female, median age 10.7 [8.0–14.5] years and 43 controls (26 female, median age 12.7 [9.2–18.2] years) matched by age (p = 0.13) and sex (p = 0.50), the median TIVLA in the SCD group (35.9 mm2 [30.7, 39.5]) was larger than controls (30.5 mm2 [27.8, 35.4], p = 0.002). In a mixed model including age, sex, hemoglobin, CBF, SCD status, and an interaction between hemoglobin and SCD status, CBF (β = 0.11, CI 0.02–0.20, p = 0.02), SCD (β = 28.02, CI 5.62–50.42, p = 0.015), and the interaction between SCD and hemoglobin (β = −2.48, CI −4.49 to −0.47, p = 0.018) were all significantly associated with increased TIVLA. Notably, TIVLA as a measure of arterial lumens is larger in children with SCD, even after adjusting for CBF in the mixed model. This implies disease-specific normative values may be needed to detect early vasculopathy.

Abstract Image

与同龄人相比,镰状细胞病儿童和年轻人的脑动脉管腔增大
患有镰状细胞病(SCD)的儿童可能出现大血管狭窄,但研究表明血管也可能扩大,可能与脑血流量(CBF)增加有关。我们使用MRI来研究在调整CBF后,SCD患者与年龄和性别匹配的同龄人相比,靠近Willis圈(颈动脉+基底动脉)的横截面总流入血管管腔面积(TIVLA)是否会增加。在36名SCD患儿中(19名女性,中位年龄为10.7[8.0-14.5]岁)和43名对照(26名女性,中位年龄为12.7[9.2-18.2]岁),按年龄(p = 0.13)和性别(p = 0.50)匹配,SCD组的中位TIVLA (35.9 mm2[30.7, 39.5])大于对照组(30.5 mm2 [27.8, 35.4], p = 0.002)。在包括年龄、性别、血红蛋白、CBF、SCD状态以及血红蛋白与SCD状态相互作用的混合模型中,CBF (β = 0.11, CI 0.02 ~ 0.20, p = 0.02)、SCD (β = 28.02, CI 5.62 ~ 50.42, p = 0.015)、SCD与血红蛋白相互作用(β = - 2.48, CI - 4.49 ~ - 0.47, p = 0.018)均与tila升高显著相关。值得注意的是,即使在混合模型中调整CBF后,作为动脉管腔测量指标的TIVLA在SCD儿童中也更大。这意味着可能需要疾病特异性的规范值来检测早期血管病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Neuroimage. Reports
Neuroimage. Reports Neuroscience (General)
CiteScore
1.90
自引率
0.00%
发文量
0
审稿时长
87 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信