Identification of Risk Factors Influencing Hemorrhage Volume in Aneurysmal Subarachnoid Hemorrhage: A Multicenter Retrospective Study

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-05-08 DOI:10.1002/brb3.70498

Chenglong Li, Yuan Wang, Tangming Peng, Jiangnan Wu, Hongyu Wang, Jian Song, Di Zhao, Guang Feng, Lei Chen

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Abstract

Objective

This multicenter retrospective study aimed to identify significant risk factors influencing hemorrhage volume in patients with aneurysmal subarachnoid hemorrhage (SAH).

Methods

A total of 891 patients diagnosed with SAH were included from multiple medical centers. Data encompassing demographic characteristics, medical history, clinical parameters at admission, and radiographic findings were collected and analyzed. Univariate and multivariate logistic regression analyses were conducted to investigate associations between various risk factors and hemorrhage volume.

Results

This study identifies several factors significantly associated with increased hemorrhage volume in patients with subarachnoid hemorrhage (SAH). Multivariate analysis revealed that diabetes (P = 0.022), hypertension (P = 0.047), and saccular aneurysm morphology (P = 0.008) were independent risk factors for high hemorrhage volume. Additionally, larger aneurysm size (maximum diameter: P = 0.007, neck diameter: P = 0.021) and higher systolic blood pressure after onset (P = 0.002) were also significant predictors of increased hemorrhage volume. Factors such as age (P = 0.05) and time interval to the first CT scan (P = 0.022) were found to be associated with hemorrhage volume in univariate analysis but did not maintain independent significance in multivariate regression.

Conclusion

This study highlights key risk factors, including diabetes, hypertension, and saccular aneurysm morphology, which independently contribute to higher hemorrhage volume in SAH patients. Management strategies focusing on early detection and control of these factors may improve clinical outcomes by reducing the risk of hemorrhagic complications. While other factors such as age and time interval to the first CT scan were associated with hemorrhage volume, they did not demonstrate independent causality in the multivariate analysis, suggesting that their role in hemorrhage volume may be secondary or context-dependent.

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影响动脉瘤性蛛网膜下腔出血出血量的危险因素：一项多中心回顾性研究

目的本多中心回顾性研究旨在确定影响动脉瘤性蛛网膜下腔出血（SAH）患者出血量的重要危险因素。方法从多个医疗中心收集确诊为SAH的891例患者。收集和分析了包括人口统计学特征、病史、入院时临床参数和影像学表现在内的数据。单因素和多因素logistic回归分析探讨各种危险因素与出血量之间的关系。结果本研究确定了与蛛网膜下腔出血（SAH）患者出血量增加显著相关的几个因素。多因素分析显示，糖尿病（P = 0.022）、高血压（P = 0.047）、囊状动脉瘤形态（P = 0.008）是高出血量的独立危险因素。此外，较大的动脉瘤尺寸（最大直径：P = 0.007，颈直径：P = 0.021）和发病后较高的收缩压（P = 0.002）也是出血增加的重要预测因素。单因素分析发现，年龄（P = 0.05）、首次CT扫描时间间隔（P = 0.022）等因素与出血量相关，但多因素回归分析未保持独立显著性。结论本研究强调了导致SAH患者出血量增加的关键危险因素，包括糖尿病、高血压和囊状动脉瘤形态。注重早期发现和控制这些因素的管理策略可以通过降低出血性并发症的风险来改善临床结果。虽然年龄和第一次CT扫描的时间间隔等其他因素与出血量有关，但在多变量分析中并未显示出独立的因果关系，这表明它们在出血量中的作用可能是次要的或依赖于环境的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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