Multienzyme cascade synthesis of ω-amino fatty acids from vegetable-derived precursors for use as nylon monomers

Yueyue Zhou, Ran Lu, Xiaoxia Gao, Lu Lin, Yongjun Wei and Xiao-Jun Ji
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引用次数: 0

Abstract

Omega-amino fatty acids (ω-AmFAs) are non-natural organic molecules with amino and carboxyl groups located at the ends of unbranched carbon chains. They are widely used in the synthesis of polymers such as polyesters and polyamides, as well as in the production of chemical products such as biofuels and pharmaceutical intermediates. In recent years, the production of such materials and other chemicals via the fermentation of renewable resources using engineered microorganisms has become a hot spot of research, as examples of emerging green and low-carbon technologies. Traditional petrochemical synthesis methods of nylon monomers often face problems such as environmental pollution, increased energy consumption and high cost. By contrast, the catalytic production of ω-AmFAs from fatty acids such as oleic acid, ricinoleic acid and lauric acid found in vegetable oils using a multienzyme cascade has the unique advantages of being environmentally friendly and having high process economics. This paper reviews multienzyme synthesis strategies of ω-AmFAs used as nylon monomers.

多酶级联合成ω-氨基脂肪酸从植物来源的前体用作尼龙单体
ω-氨基脂肪酸(ω-AmFAs)是一种非天然有机分子,其氨基和羧基位于未支链的碳链末端。它们广泛用于聚酯和聚酰胺等聚合物的合成,以及生物燃料和医药中间体等化学产品的生产。近年来,利用工程微生物通过可再生资源发酵生产此类材料和其他化学品已成为研究热点,作为新兴绿色低碳技术的例子。传统的石油化工合成尼龙单体的方法往往面临环境污染、能耗增加和成本高等问题。相比之下,用多酶级联法从植物油中的油酸、蓖麻油酸和月桂酸等脂肪酸催化生产ω-AmFAs具有环境友好和工艺经济高的独特优势。本文综述了ω-AmFAs作为尼龙单体的多酶合成策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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