{"title":"Proton imaging at the end of the proton range","authors":"F.L.S. Cerutti , V.V. Denyak , S.A. Paschuk , H.R. Schelin , J.A.P. Setti , J.T. Assis","doi":"10.1016/j.radphyschem.2025.112909","DOIUrl":null,"url":null,"abstract":"<div><div>Since the earliest studies on the usage of protons for image production, it was declared that to take advantage of proton beam it is necessary to choose an initial proton energy close to the minimum possible value, i.e., to work at the end of the proton range, where the proton flux changes very steeply. However, this idea was declared, but was not investigated. In the present work, we study the efficiency of image production at the end of the proton range with the three physical observables that can be used for such purpose: the mean energy of exit proton, number of protons and total energy of exit protons. By using a Monte Carlo simulation, we studied the uncertainties in the determination of object thickness with these observables at the conditions typical for medical imaging. At the area before the end of the proton range, the uncertainty in thickness determination obtained analysing the mean energy of exit proton is significantly less than the uncertainty obtained for the number of protons. At the end of the range, the number of protons becomes preferable for the measurement of the absorber thickness. The precision of the total energy of exit protons matches the precision of the number of protons at the end of the range and the precision of the mean energy of exit proton outside this region. Any effect that justifies the idea to work at the end of the proton range was not observed.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"236 ","pages":"Article 112909"},"PeriodicalIF":2.8000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiation Physics and Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0969806X25004013","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Since the earliest studies on the usage of protons for image production, it was declared that to take advantage of proton beam it is necessary to choose an initial proton energy close to the minimum possible value, i.e., to work at the end of the proton range, where the proton flux changes very steeply. However, this idea was declared, but was not investigated. In the present work, we study the efficiency of image production at the end of the proton range with the three physical observables that can be used for such purpose: the mean energy of exit proton, number of protons and total energy of exit protons. By using a Monte Carlo simulation, we studied the uncertainties in the determination of object thickness with these observables at the conditions typical for medical imaging. At the area before the end of the proton range, the uncertainty in thickness determination obtained analysing the mean energy of exit proton is significantly less than the uncertainty obtained for the number of protons. At the end of the range, the number of protons becomes preferable for the measurement of the absorber thickness. The precision of the total energy of exit protons matches the precision of the number of protons at the end of the range and the precision of the mean energy of exit proton outside this region. Any effect that justifies the idea to work at the end of the proton range was not observed.
期刊介绍:
Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing.
The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.