Study of directional pulsed neutron flux generation for BNCT using a high-intensity lithium beam

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-04-29 DOI:10.1016/j.apradiso.2025.111872

Masahiro Okamura , Antonino Cannavo , Shunsuke Ikeda , Takeshi Kanesue , Toshiro Sakabe , Kazumasa Takahashi , Giovanni Ceccio , Madhawa Horana Gamage

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引用次数: 0

Abstract

This paper introduces a novel neutron production system for Boron Neutron Capture Therapy (BNCT) that employs a lithium beam in inverse kinematics to generate forward-directed neutrons through the ⁷Li (p,n)⁷Be reaction. The system utilizes a thin polypropylene target and an optimized beam configuration to achieve high neutron yield and precise directional control. A tape target mechanism is incorporated to effectively manage thermal loads, ensuring stable and reliable operation. The proposed system could offer substantial advantages over conventional neutron sources, including enhanced neutron directionality and a reduced shielding requirement. This approach increases the potential for precise tumor targeting while minimizing exposure to surrounding healthy tissues, paving the way for a more accessible and efficient BNCT treatment option.

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利用高强度锂束流产生BNCT定向脉冲中子通量的研究

本文介绍了一种用于硼中子捕获治疗（BNCT）的新型中子产生系统，该系统采用反向运动的锂束通过7Li (p,n)7Be反应产生正向中子。该系统利用薄型聚丙烯靶和优化的光束配置来实现高中子产率和精确的方向控制。采用带靶机构，有效管理热负荷，确保运行稳定可靠。与传统的中子源相比，该系统具有显著的优势，包括增强的中子方向性和降低的屏蔽要求。这种方法增加了精确肿瘤靶向的潜力，同时最大限度地减少了对周围健康组织的暴露，为更容易获得和有效的BNCT治疗选择铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.