Free carrier-enhanced Bi/Bi2S3 nanoparticles enable precise OCT catheter-guided interventional photothermal therapy for colorectal cancer

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia Pub Date : 2025-04-12 DOI:10.1016/j.actbio.2025.04.018

Xiaoyu Huang , Fan Yang , Beibei Gao , Wei Ge , Lu Gao , Jigang Wu , Shengxian Tu , Fu Wang

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引用次数: 0

Abstract

Current clinical colorectal cancer treatments usually possess unsatisfactory effects, mainly because of unavoidable surgical trauma and multidrug resistance. Precise and minimally invasive theragnostic technology has advanced through miniaturized catheter intervention with imaging-guided treatment methods; however, previously reported approaches cannot simultaneously perform in situ real-time imaging and therapy. We proposed a strategy of 0.9 mm catheter-based optical coherence tomography imaging-guided interventional photothermal therapy at 1310 nm for orthotopic colorectal cancer. Specifically, folate-modified Bi/Bi₂S₃ nanoparticles showed intense scattering signals and local hyperpyrexia under 1310 nm laser irradiation in vitro and in vivo due to the localized surface plasmon resonance effect, enabling imaging-guided precise tumor treatment. Histopathological and blood biochemistry analyses confirmed the high biosafety and negligible long-term toxicity of Bi/Bi₂S₃ nanoparticles. This new method offers a feasible methodology for catheter-based precise interventional photon theragnostics.

Statement of significance

Emerging minimally invasive techniques have been explored for the treatment of colorectal cancer (CRC); however, these reported approaches cannot reach the requirement of precise orthotopic cancer treatment due to the lack of in situ real-time imaging guidance. This study proposes a 0.9 mm catheter-based OCT imaging-guided interventional photothermal therapy (IPTT) strategy at 1310 nm for treating orthotopic CRC. Folate-modified plasmonic Bi/Bi₂S₃ nanoparticles enable real-time imaging-guided IPTT by providing strong scattering signals and local hyperthermia. This approach allows simultaneous transmission of imaging and therapy light in the same optical fiber, offering a promising method for precise CRC theragnostics and addressing the gap of in situ real-time imaging during IPTT.

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游离载流子增强的Bi/Bi2S3纳米颗粒可用于结肠直肠癌的精确OCT导管引导介入光热治疗

目前临床对结直肠癌的治疗效果往往不理想，主要原因是手术创伤不可避免和多药耐药。通过微型导管介入和成像引导的治疗方法，精确和微创的诊断技术得到了进步；然而，先前报道的方法不能同时进行原位实时成像和治疗。我们提出了一种基于0.9 mm导管的光学相干断层成像引导1310 nm介入光热治疗原位结直肠癌的策略。具体而言，叶酸修饰的Bi/Bi2S3纳米颗粒在1310 nm激光照射下，由于局部表面等离子体共振效应，在体外和体内表现出强烈的散射信号和局部高热，可以实现成像引导的精确肿瘤治疗。组织病理学和血液生化分析证实了Bi/Bi2S3纳米颗粒的高生物安全性和可忽略的长期毒性。这种新方法为基于导管的精确介入光子诊断提供了一种可行的方法。新出现的微创技术已经被用于结肠直肠癌（CRC）的治疗；然而，由于缺乏原位实时成像引导，这些报道的方法无法达到精确原位肿瘤治疗的要求。本研究提出了一种基于0.9 mm导管的1310 nm OCT成像引导介入光热治疗（IPTT）策略，用于治疗原位结直肠癌。叶酸修饰的等离子体Bi/Bi2S3纳米颗粒通过提供强散射信号和局部热疗来实现实时成像引导的IPTT。该方法允许在同一光纤中同时传输成像和治疗光，为精确的CRC诊断提供了一种有希望的方法，并解决了IPTT期间原位实时成像的空白。

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来源期刊

Acta Biomaterialia 工程技术-材料科学：生物材料

CiteScore

16.80

自引率

3.10%

发文量

776

审稿时长

30 days

期刊介绍： Acta Biomaterialia is a monthly peer-reviewed scientific journal published by Elsevier. The journal was established in January 2005. The editor-in-chief is W.R. Wagner (University of Pittsburgh). The journal covers research in biomaterials science, including the interrelationship of biomaterial structure and function from macroscale to nanoscale. Topical coverage includes biomedical and biocompatible materials.