Solvability Measurement, Solvent Impact, Thermodynamic Modeling, and Special Solvation of Benzohydrazide in Aqueous Cosolvent Combinations of Some Alcohols

Abstract

This work employed a gravimetric approach to determine the solid–liquid phase equilibrium of benzohydrazide (BH) in binary solvent systems (methanol + water, ethanol + water, propan-1-ol + water, and propan-2-ol + water) under 101.2 kPa between 283.15 and 323.15 K. The findings displayed that BH becomes more soluble at higher temperature and less soluble with increased mole fraction of water in the binary solvent mixtures. Concurrently, the impact of solvent on the mole fraction solubility of BH in solution was examined by utilizing the KAT model. The findings show that the capability of the solvent to form hydrogen bonds (α) and the cavity term, which reflects the molecular contact energy between solvent molecules, have the greatest influence on the solvent effect for BH. The experimental data were correlated utilizing the Jouyban–Acree, Jouyban–Acree-van’t Hoff, Apelblat–Jouyban–Acree, and Ma models. The low values for the average relative deviation (RAD %) (≤1.03, ≤1.99, ≤1.86, and ≤1.98, respectively) show that the experimental solubility data for BH in the four binary solvent mixes strongly align with the correlated data using the selected four models. Inverse Kirkwood–Buff integrals were utilized to compute the specific solvation parameters.