Genetic Variation in Drug Targets: Are We Ready for the Era of Precision Medicinal Chemistry?

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-04-10 DOI:10.1021/acsmedchemlett.5c0015310.1021/acsmedchemlett.5c00153

Clinton G. L. Veale, and , Adrienne L. Edkins,

引用次数: 0

Abstract

Natural genetic variations profoundly impact drug target interactions causing variations in in vitro biological data. The overall occurrence or “rare genetic variation” is common and enriched within population groups. Incorporating population-level genetic information earlier into the drug discovery pipeline would allow medicinal chemists to contribute to the precision medicine movement, designing drugs with more population relevance.

查看原文本刊更多论文

药物靶点的遗传变异：我们准备好进入精准药物化学时代了吗？

自然遗传变异深刻地影响药物靶标相互作用，导致体外生物学数据的变化。总体发生或“罕见遗传变异”在人群群体中是普遍和丰富的。将人群水平的遗传信息更早地纳入药物发现管道，将使药物化学家能够为精准医学运动做出贡献，设计出与人群更相关的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.