Sound-controlled fluidic processor

IF 11.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-05-07 DOI:10.1126/sciadv.adv6314

Hengjia Zhu, Qiyu Deng, Junzhi Li, Ling Yang, Hegeng Li, Zhipeng Zhao, Zuochen Wang, Chunlin Pang, Yiyuan Zhang, Vincent Chi-Hang Lui, Wei Li, Xiaobo Yin, Liqiu Wang

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引用次数: 0

Abstract

Precision processing of various liquids while maintaining their purity holds immense potential for many applications. However, liquids tend to leave residues that contaminate handling tools and compromise volumetric precision, necessitating contactless strategies to prevent liquid loss. Biological and chemical samples carried by fluids can be sensitive to physical stimuli, demanding mild but effective means to preserve integrity. Here, we report a sound-controlled fluidic processor for complete and well-controlled microfluidic functions, including moving, merging, mixing, and cleaving, in contactless and harmless manners. The processor generates an acoustophoretic force field that serves as a versatile toolbox for manipulating droplets with surface tension from 17.9 to 72 millinewtons per meter and volume from 1 nanoliter to 3 milliliters, offering a wealth of operations crucial to fundamental biomedical and chemical practices.

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声控流控处理器

各种液体的精密加工，同时保持其纯度具有许多应用的巨大潜力。然而，液体往往会留下残留物，污染处理工具并影响体积精度，因此需要非接触式策略来防止液体损失。液体携带的生物和化学样品可能对物理刺激敏感，需要温和但有效的方法来保持完整性。在这里，我们报道了一种声控流体处理器，它可以实现完整的、控制良好的微流体功能，包括移动、合并、混合和切割，以无接触和无害的方式。该处理器产生声光力场，作为一个多功能工具箱，可以操纵表面张力从17.9到72毫牛顿/米，体积从1纳升到3毫升的液滴，为基础生物医学和化学实践提供大量至关重要的操作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.