Prominent role of PM10 in the link between air pollution and incident Parkinson’s Disease

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-05-07 DOI:10.1038/s41531-025-00935-y

Alessandro Gialluisi, Simona Costanzo, Maria Ilenia De Bartolo, Giovanni Veronesi, Matteo Renzi, Assuntina Cembalo, Alfonsina Tirozzi, Stefania Falciglia, Moreno Ricci, Americo Bonanni, Francesco Martone, Gaetano Zazzaro, Antonietta Pepe, Daniele Belvisi, Marco Mario Ferrario, Francesco Gianfagna, Chiara Cerletti, Maria Benedetta Donati, Stefania Massari, Alfredo Berardelli, Giovanni de Gaetano, Licia Iacoviello

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Abstract

Air pollution has been associated with Parkinson’s Disease (PD) risk, although this relationship remains unclear. We estimated yearly levels of exposure to ten air pollutants (period 2006–2018) in an Italian population cohort, the Moli-sani study (N = 24,325; ≥35 years; 51.9% women), and derived three principal components, testing their associations with incident PD risk over 23,841 participants (213 cases, median(IQR) follow-up 11.2(2.0) years). This revealed a statistically significant association of PC1 (explaining 38.2% of common variance, tagging PM10 levels), independent on sociodemographic, professional and lifestyles covariates (Hazard Ratio [95%CI] = 1.04[1.02–1.07]). The association was confirmed testing average PM10 levels during follow-up (18[13–24]% increase of PD risk per 1 μg/m³ increase of PM10). Among different circulating markers, lipoprotein a explained a significant proportion of this association (2.8[0.9; 8.4]%). These findings suggest PM10 as a target to lower PD risk at the population level and a potential implication of lipoprotein a in PD etiology.

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PM10在空气污染与帕金森病发病之间的关系中的突出作用

空气污染与帕金森病（PD）风险有关，尽管这种关系尚不清楚。我们估计了意大利人口队列中10种空气污染物的年暴露水平（2006-2018年），Moli-sani研究(N = 24,325；≥35年;51.9%女性)，并推导出三个主要成分，在23,841名参与者（213例，中位（IQR）随访11.2（2.0）年）中测试其与PD事件风险的关联。这揭示了PC1（解释38.2%的共同方差，标记PM10水平）与社会人口统计学、职业和生活方式协变量的显著相关性（风险比[95%CI] = 1.04[1.02-1.07]）。随访期间检测PM10平均水平证实了这种关联（PM10每增加1 μg/m3， PD风险增加18[13-24]%）。在不同的循环标志物中，脂蛋白a解释了这种关联的显著比例(2.8[0.9；8.4) %)。这些发现表明PM10在人群水平上是降低PD风险的靶标，并且在PD病因学中具有脂蛋白a的潜在含义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.