A Case of Small Cell Carcinoma of Bladder With Significant Tumor Reduction Following Combination Chemotherapy and Radiation Therapy

Q4 Medicine

IJU Case Reports Pub Date : 2025-04-14 DOI:10.1002/iju5.70031

Rintaro Yoshitake, Syunsuke Taguchi, Yoshimasa Harada

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Abstract

Introduction

Small cell carcinoma of the bladder (SCCB) is a rare and aggressive disease with no established standard treatment. We report a case of SCCB that initially progressed with chemotherapy but responded well to a combination of chemotherapy and radiotherapy.

Case Presentation

A 62-year-old man presented with painless gross hematuria. Transurethral resection of the bladder tumor (TURBT) confirmed SCCB. Gemcitabine-carboplatin (GEM-CBDCA) and pembrolizumab were ineffective, leading to rapid tumor progression. The patient developed bladder tamponade and obstructive renal failure. Emergency radiotherapy (30 Gy) controlled bleeding, and etoposide-carboplatin chemotherapy resulted in significant tumor shrinkage.

Conclusion

This case highlights the potential effectiveness of etoposide-carboplatin and radiotherapy in SCCB, especially in cases resistant to other treatments. Further studies are needed to establish optimal treatment strategies for SCCB.

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膀胱小细胞癌经放化疗后肿瘤明显缩小1例

膀胱小细胞癌（SCCB）是一种罕见的侵袭性疾病，目前尚无标准治疗方法。我们报告一例SCCB，最初与化疗进展，但对化疗和放疗联合反应良好。一例62岁男性无痛性肉眼血尿。经尿道膀胱肿瘤切除术（turt）证实SCCB。吉西他滨-卡铂（GEM-CBDCA）和派姆单抗无效，导致肿瘤快速进展。患者出现膀胱填塞和阻塞性肾衰竭。急诊放疗（30 Gy）控制出血，依托泊肽-卡铂化疗使肿瘤明显缩小。结论本病例突出了依托泊滨-卡铂联合放疗治疗SCCB的潜在疗效，特别是对其他治疗方法耐药的病例。需要进一步的研究来确定SCCB的最佳治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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