Derya Demir, Joanna Antos, František Švec, Hana Sklenářová
{"title":"Recent Developments in Deep Eutectic Solvents Applications in Liquid Chromatography: 2019–2025","authors":"Derya Demir, Joanna Antos, František Švec, Hana Sklenářová","doi":"10.1002/jssc.70160","DOIUrl":null,"url":null,"abstract":"<p>Deep eutectic solvents (DES) are used as mobile phase and stationary phase modifiers, or as for the stationary phase itself for thin layer/liquid/supercritical chromatography. Their specific properties can improve the separation selectivity, reduce peak tailing, and shorten the separation time. In terms of environmental impact, the advantages of DES are based on their biodegradability, recyclability, and stability in terms of mechanical/chemical/thermal properties. The disadvantages are related to higher viscosity and degradation in aqueous solutions. This review focuses on works that have been published since 2019, the year the excellent comprehensive review by Cai and Qiu was printed. Selected parameters are discussed that should be considered when DES are preferred over commonly used mobile and stationary phases due to green chemistry trends, while taking into account their limitations in modern LC separations. This review also centres on critical aspects of DES applications in the field of liquid and supercritical fluid chromatographic separations.</p>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 5","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jssc.70160","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of separation science","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jssc.70160","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Deep eutectic solvents (DES) are used as mobile phase and stationary phase modifiers, or as for the stationary phase itself for thin layer/liquid/supercritical chromatography. Their specific properties can improve the separation selectivity, reduce peak tailing, and shorten the separation time. In terms of environmental impact, the advantages of DES are based on their biodegradability, recyclability, and stability in terms of mechanical/chemical/thermal properties. The disadvantages are related to higher viscosity and degradation in aqueous solutions. This review focuses on works that have been published since 2019, the year the excellent comprehensive review by Cai and Qiu was printed. Selected parameters are discussed that should be considered when DES are preferred over commonly used mobile and stationary phases due to green chemistry trends, while taking into account their limitations in modern LC separations. This review also centres on critical aspects of DES applications in the field of liquid and supercritical fluid chromatographic separations.
期刊介绍：
The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
