Pathological Aging of Patients With Amyotrophic Lateral Sclerosis: A Preliminary Longitudinal Study

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-05-07 DOI:10.1002/brb3.70484

Sana Mohammadi, Sadegh Ghaderi, Farzad Fatehi, Sanjay Kalra, Seyed Amir Hossein Batouli

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引用次数: 0

Abstract

Objective

This longitudinal study investigated pathological brain aging in amyotrophic lateral sclerosis (ALS) by evaluating disparities between chronological age and deep learning-derived brain structure age (BSA) and exploring associations with cognitive and functional decline.

Methods

Ten limb-onset ALS patients (seven males) and 10 demographically matched healthy controls (HCs) underwent structural magnetic resonance imaging (sMRI) and cognitive assessments at baseline and follow-up. The BSA was estimated using the validated volBrain platform. Cognitive domains (language, verbal fluency, executive function, memory, and visuospatial skills) and global cognition (Persian adaptive Edinburgh Cognitive and Behavioral ALS Screen [ECAS] total score) were assessed along with functional status (ALSFRS-R).

Results

ALS patients exhibited significant BSA-chronological age disparities at baseline (Δ = +7.31 years, p = 0.009) and follow-up (Δ = +8.39 years, p = 0.003), with accelerated BSA progression over time (p = 0.004). The HCs showed no such disparities (p = 0.931). Longitudinal BSA increases were correlated with executive function decline (r = −0.651, p = 0.042). Higher education predicted preserved language (r = 0.831, p = 0.003) and verbal fluency (r = 0.738, p = 0.015). ALSFRS-R decline paralleled visuospatial (r = 0.642, p = 0.045) and global cognitive deterioration (r = 0.667, p = 0.035).

Conclusions

ALS is characterized by accelerated structural brain aging that progresses independently of chronological age and is correlated with executive dysfunction. Education may mitigate cognitive decline, while motor functional deterioration aligns with visuospatial and global cognitive impairments. BSA has emerged as a potential biomarker for tracking pathological aging trajectories in ALS, warranting validation using larger cohorts.

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肌萎缩侧索硬化患者病理性衰老：一项初步的纵向研究

目的通过评价实足年龄与深度学习衍生脑结构年龄（BSA）的差异，探讨其与认知和功能衰退的关系，对肌萎缩侧索硬化症（ALS）的病理性脑衰老进行纵向研究。方法10例肢体起病的ALS患者（7名男性）和10例人口统计学匹配的健康对照（hc）在基线和随访时进行了结构磁共振成像（sMRI）和认知评估。使用经过验证的volBrain平台估计BSA。认知领域（语言、言语流畅性、执行功能、记忆和视觉空间技能）和整体认知（波斯适应性爱丁堡认知和行为ALS筛查[ECAS]总分）与功能状态（ALSFRS-R）一起进行评估。结果ALS患者在基线时（Δ = +7.31岁，p = 0.009）和随访时（Δ = +8.39岁，p = 0.003）表现出显著的BSA-时间年龄差异，随着时间的推移BSA进展加速（p = 0.004）。hcc无差异（p = 0.931）。纵向BSA升高与执行功能下降相关（r = - 0.651, p = 0.042）。高等教育可以预测语言的保存（r = 0.831, p = 0.003）和语言流畅性（r = 0.738, p = 0.015）。ALSFRS-R的下降与视觉空间（r = 0.642, p = 0.045）和整体认知衰退（r = 0.667, p = 0.035）平行。结论ALS的特点是脑结构加速老化，其进展独立于实足年龄，并与执行功能障碍相关。教育可以减轻认知能力下降，而运动功能恶化与视觉空间和整体认知障碍相一致。BSA已成为追踪ALS病理性衰老轨迹的潜在生物标志物，需要使用更大的队列进行验证。

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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