Delayed villous maturation with and without fetal demise: A case report of three successive pregnancies

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-05-06 DOI:10.1111/jog.16308

M. C. Marijnen, W. Ganzevoort, S. J. Gordijn, L. E. van der Meeren

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引用次数: 0

Abstract

This case study examined three subsequent pregnancies with delayed villous maturation (DVM) resulting in infants either large for gestational age (LGA) or appropriate for gestational age. A perinatal pathologist histopathologically reviewed the placentas using the Amsterdam Consensus Criteria. The first pregnancy ended in a term fetal demise of an LGA infant due to severe asphyxia associated with idiopathic DVM. Due to the history of stillbirth and DVM, labor was induced at 36 weeks of gestation in the second and third pregnancies. The second and third pregnancies resulted in liveborn infants with varying weight profiles despite similar placental lesions. All three placentas showed DVM with positive CD15 immunostaining. Additionally, the second and third placentas exhibited villitis of unknown etiology. This case report underscores the importance of structured histologic placental examination following complicated pregnancies by a perinatal pathologist.

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延迟绒毛成熟伴或不伴胎儿死亡：一个连续三次妊娠的病例报告

本病例研究检查了三个随后的怀孕与延迟绒毛成熟（DVM）导致婴儿大胎龄（LGA）或胎龄合适。围产期病理学家使用阿姆斯特丹共识标准对胎盘进行组织病理学检查。由于特发性DVM相关的严重窒息，第一次妊娠以LGA婴儿的足月胎儿死亡结束。由于死产和DVM病史，第二次和第三次妊娠在妊娠36周引产。第二次和第三次妊娠导致活产婴儿体重不同，尽管胎盘病变相似。三个胎盘均显示DVM， CD15免疫染色阳性。此外，第二和第三胎盘表现出不明原因的绒毛炎。本病例报告强调了围产期病理学家在复杂妊娠后进行结构化胎盘组织学检查的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.