The synthesis, spectral, structural and antimicrobial properties of nanocolloids of carboxybetaine calix[4]resorcine with silver nanoparticles and silver ions
Z. R. Gilmullina, A. T. Kamaleeva, A. P. Lyubina, A. A. Parfenov, A. D. Voloshina, I. R. Nizameev, J. E. Morozova, A. Yu. Ziganshina, D. V. Zakharychev, A. T. Gubaidullin, I. S. Antipin
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Abstract
In the face of the growth of the multi-resistant bacteria, the search for the effective antibacterial agents has become one of the main challenges of the modern society. Silver nanoparticles are known to be effective antibacterial agents, but their use is associated with the risk of the toxic effects on the mammalian cells. Therefore, it is essential to synthesize the silver nanoparticles that are stabilized by the low-toxic capping agents. In this study, we used a low-toxic carboxybetaine derivative of tetrapentylcalix[4]resorcine (C5-CB) as a capping agent for AgNPs. It is found that the syntheses of the AgNPs resulted in the formation of the nanocolloids (NCs) containing silver nanoparticles, stabilized by the C5-CB, and the complexes of the silver ions and the C5-CB. The NCs are characterized by the absorption spectroscopy, DLS, XRPD, TEM, IR, and TGA/DSC methods. It is shown that an Ag+/C5-CB molar ratio affects the size of the NCs and the AgNPs, their stability, antimicrobial activity, and cytotoxicity. The NCs exhibit bacteriostatic activity against strains of Staphylococcus aureus with multiple drug resistance (MRSA-1 and MRSA-2) as well as a bactericidal activity (against Sa, Ef, and Ec) and a fungicidal activity (against Ca).
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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