Hump-inspired ingestible magnetic capsules enable circular nutrition storage and supply for short bowel syndrome treatment

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 2025-05-03 DOI:10.1016/j.biomaterials.2025.123389

Jiahao Dai , Na Li , Bo Cai , Yueying Yang , Wenyu Liu , Lin Wang , Jianfeng Zang , Zheng Wang

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Abstract

Parenteral nutrition and intestinal transplantation, essential clinical interventions for short bowel syndrome (SBS) patients, are limited by various complications such as impaired intestinal barrier, metabolic disorder, catheter-associated infection, and allogenic rejection, leading to inferior therapeutic outcomes. Here, inspired by the camel hump, an ingestible magnetic capsule (IMC) consisting of thermosensitive hydrogel microparticles (MPs) based on poly(N-isopropylacrylamide) and acrylamide and a magnetic shell made of NdFeB and polyvinyl alcohol is proposed to enable circular nutrition storage and supply to optimize enteral nutrition for SBS treatment. Thermosensitive hydrogel MPs absorb excessive fluid and subsequently release nutrients in response to the heat generated by the photothermal effect of the magnetic shell under near-infrared irradiation. IMC can be localized and retained in the small intestine by the attraction between the magnetic shell and the external ferromagnet. In a SBS rat model, consistent nutrition optimization significantly relieves the weight loss, improves the nutrition-related serological markers, and facilitates the adaptation of the remnant small intestinal epithelium. This study offers a proof of principle for the use of ingestible capsules for nutrient storage and supply, providing a potential strategy for SBS treatment.

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驼峰启发的可摄取磁胶囊使循环营养储存和供应短肠综合征的治疗

肠外营养和肠移植是短肠综合征（SBS）患者必不可少的临床干预措施，但由于肠道屏障受损、代谢紊乱、导管相关感染和同种异体排斥反应等各种并发症的限制，导致治疗效果不佳。本文受骆驼驼峰的启发，提出了一种可摄取的磁胶囊（IMC），该胶囊由基于聚n -异丙基丙烯酰胺和丙烯酰胺的热敏水凝胶微粒（MPs）和由钕铁硼和聚乙烯醇制成的磁壳组成，可实现循环营养储存和供应，以优化SBS治疗的肠内营养。热敏水凝胶MPs吸收过多的流体，随后释放营养物质，以响应近红外照射下磁壳的光热效应产生的热量。IMC可以通过磁性外壳与外部铁磁体之间的吸引力定位并保留在小肠内。在SBS大鼠模型中，一致的营养优化可显著减轻体重，改善营养相关血清学指标，促进残余小肠上皮的适应。本研究为利用可摄取胶囊进行营养储存和供应提供了原理证明，为SBS的治疗提供了潜在的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.