{"title":"Microbial polysaccharides biosynthesis and their regulatory strategies","authors":"Dafang Yin, Yadong Zhong, Jielun Hu","doi":"10.1016/j.ijbiomac.2025.143013","DOIUrl":null,"url":null,"abstract":"<div><div>Microbial polysaccharides hold significant potential for various applications, including food, cosmetics, petroleum, and pharmaceuticals. A deeper understanding of their biosynthetic pathways and regulatory strategies is crucial for enhancing production efficiency and reducing associated costs. To summarize synthetic biological modification strategies for microbial polysaccharides from a hierarchical perspective, this review classifies these polymers into three categories based on the depths of carried out research regarding their biosynthetic pathways and regulatory strategies, i.e., (1) microbial polysaccharides with well-elucidated biosynthetic pathways, (2) microbial polysaccharides with well-elucidated precursor sugar biosynthetic pathways but synthase-encoding genes incompletely understood, and (3) those whose biosynthesis depends on a single synthetic enzyme. We systematically summarize the biosynthetic pathways of these three categories and provide insights into yield-improvement strategies. This review aims to serve as a valuable reference for metabolic regulation of microbial polysaccharides and to facilitate future advances in their production.</div></div>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"308 ","pages":"Article 143013"},"PeriodicalIF":7.7000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biological Macromolecules","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0141813025035652","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Microbial polysaccharides hold significant potential for various applications, including food, cosmetics, petroleum, and pharmaceuticals. A deeper understanding of their biosynthetic pathways and regulatory strategies is crucial for enhancing production efficiency and reducing associated costs. To summarize synthetic biological modification strategies for microbial polysaccharides from a hierarchical perspective, this review classifies these polymers into three categories based on the depths of carried out research regarding their biosynthetic pathways and regulatory strategies, i.e., (1) microbial polysaccharides with well-elucidated biosynthetic pathways, (2) microbial polysaccharides with well-elucidated precursor sugar biosynthetic pathways but synthase-encoding genes incompletely understood, and (3) those whose biosynthesis depends on a single synthetic enzyme. We systematically summarize the biosynthetic pathways of these three categories and provide insights into yield-improvement strategies. This review aims to serve as a valuable reference for metabolic regulation of microbial polysaccharides and to facilitate future advances in their production.
期刊介绍:
The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.