Design of Spatial pore structures in Micro-Arc oxidation coatings of Ti implant for nanoparticle drug delivery

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design Pub Date : 2025-04-25 DOI:10.1016/j.matdes.2025.113992

Shuangshuang Zhang, Wei Shi, Fei Liu, Song Xiang

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Abstract

Medical titanium alloy implants, with insufficient antibacterial and wear-resistant properties, can lead to implant-associated infections (IAI), reducing their lifespan. Thus, developing surface coatings with both antibacterial and wear-resistant properties is crucial. In this study, MAO coatings were fabricated at different voltages, and their wear resistance was systematically evaluated. Drug-loaded mesoporous silica nanoparticles were integrated into the MAO coating structure to develop drug-loaded coatings, and the drug release behavior was investigated under both static and wear conditions. The results demonstrated that MAO coatings fabricated at higher voltages exhibited denser pore structures, increased thickness, and enhanced wear resistance. Notably, the coating prepared at 360 V showed superior pore interconnectivity, which facilitated efficient drug loading and sustained release during wear. These findings provide valuable insights for the design of wear-resistant and antibacterial coatings for titanium alloy implants.

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钛植入物微弧氧化涂层纳米给药空间孔结构设计

医用钛合金植入物抗菌和耐磨性能不足，可能导致植入物相关感染（IAI），缩短其使用寿命。因此，开发具有抗菌和耐磨性能的表面涂层至关重要。在本研究中，制备了不同电压下的MAO涂层，并对其耐磨性进行了系统评价。将载药介孔二氧化硅纳米颗粒整合到MAO涂层结构中，制备载药涂层，并在静态和磨损条件下研究其药物释放行为。结果表明，在较高电压下制备的MAO涂层具有更致密的孔隙结构，厚度增加，耐磨性增强。值得注意的是，在360 V下制备的涂层表现出优异的孔隙互联性，这有助于有效的药物加载和在磨损过程中持续释放。这些发现为钛合金种植体耐磨抗菌涂层的设计提供了有价值的见解。

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来源期刊

Materials & Design Engineering-Mechanical Engineering

CiteScore

14.30

自引率

7.10%

发文量

1028

审稿时长

85 days

期刊介绍： Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.