Heat stress effects on the immune system of older adults: A systematic literature review

IF 3.9

Experimental gerontology Pub Date : 2025-05-06 DOI:10.1016/j.exger.2025.112777

Rabab Awad , Assaf Suberry , Ahmad Abu-Akel , Liat Ayalon

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引用次数: 0

Abstract

Objectives

We examined the evidence from experimental and cohort studies concerning the associations between heat stress and immune vulnerability in older adults.

Research design and methods

A systematic search was performed in 6 academic databases, covering all papers that were published until April 2024. We included studies that explored immune-related outcomes associated with climate change, mainly heat shock, heat exposure, extreme temperature and global warming, among older adults, aged 65 and over. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for systematic reviews were followed to select the studies. Records that retained the exact same search terms from databases were imported into COVIDENCE software and were screened by two independent raters. Major findings were identified and synthesised.

Results

Fifteen papers were considered eligible for full-text evaluation, and 4 papers met the inclusion criteria and were included in the analysis. Studies mainly point to age-related dysregulation in heat induced response of subgroups of interleukins and heat shock proteins (hsps).

Discussion and implications

Heat stress may directly affect the regulatory function of older adults' immune system that plays a critical rule in the course of infections and inflammatory diseases. However, this review points to a paucity of relevant studies among older adults.

查看原文本刊更多论文

热应激对老年人免疫系统的影响：系统的文献综述

目的：我们检查了来自实验和队列研究的证据，这些研究涉及老年人热应激和免疫脆弱性之间的关系。研究设计与方法系统检索6个学术数据库，检索截止到2024年4月发表的所有论文。我们纳入了在65岁及以上的老年人中探讨与气候变化相关的免疫相关结果的研究，主要是热休克、热暴露、极端温度和全球变暖。按照系统评价的首选报告项目和荟萃分析（PRISMA）指南选择研究。从数据库中保留完全相同搜索词的记录被导入到covid - ence软件中，并由两名独立评级员进行筛选。确定并综合了主要发现。结果15篇论文符合全文评价标准，4篇论文符合纳入标准，被纳入分析。研究主要指出白介素和热休克蛋白（hsps）亚群热诱导反应的年龄相关失调。应激可直接影响老年人免疫系统的调节功能，而免疫系统在感染和炎症性疾病的发生过程中起着至关重要的作用。然而，这篇综述指出，在老年人中缺乏相关研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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