Comparative efficacy of drug-eluting stents vs. bare-metal stents in symptomatic vertebral artery stenosis: A prospective single-center study

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neuroscience Pub Date : 2025-05-05 DOI:10.1016/j.jocn.2025.111299

Shanquan Jing , Bo Jia , Kang An , Nanding Li , Haiyan Guo , Xiaole Li , Jiwei Wang , Wei Liu

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Abstract

Objective

To explore the safety, efficacy of drug-eluting stents and bare-metal stents in the treatment of vertebral artery stenosis, and the influencing factors of in-stent restenosis.

Methods

From June 2022 to October 2023, 129 patients undergoing vertebral artery stent implantation in the Department of Neurosurgery of the First Hospital of Hebei Medical University were randomly divided into the drug-eluting stent group and the bare-metal stent group using a randomized controlled method and followed up. The clinical data of the patients were recorded and divided into the stenosis group and the non-stenosis group according to whether in-stent restenosis occurred after surgery. Through Logistic regression analysis, the risk factors affecting in-stent restenosis were analyzed.

Results

All stents were successfully implanted, and there were no puncture site hematoma, intracranial hemorrhage, or death events after surgery. The incidence of in-stent restenosis in the drug-eluting stent group was significantly lower than that in the bare-metal stent group (4.8% vs 31.1%). Multivariate regression analysis confirmed that the bare-metal stent group was an independent risk factor for in-stent restenosis. In addition, contralateral vertebral artery stenosis is also an important risk factor.

Conclusion

Stent implantation is a safe and effective method for treating patients with symptomatic vertebral artery stenosis who are poorly controlled by drugs, and drug-eluting stents can significantly reduce the incidence of in-stent restenosis.

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药物洗脱支架与裸金属支架治疗症状性椎动脉狭窄的比较疗效：一项前瞻性单中心研究

目的探讨药物洗脱支架与裸金属支架治疗椎动脉狭窄的安全性、有效性及支架内再狭窄的影响因素。方法选取河北医科大学第一医院神经外科于2022年6月至2023年10月行椎动脉支架植入术的患者129例，采用随机对照法随机分为药物洗脱支架组和裸金属支架组，并进行随访。记录患者的临床资料，根据术后是否发生支架内再狭窄分为狭窄组和非狭窄组。通过Logistic回归分析，分析影响支架内再狭窄的危险因素。结果所有患者均成功植入支架，无穿刺部位血肿、颅内出血及术后死亡事件发生。药物洗脱支架组支架内再狭窄发生率明显低于裸金属支架组（4.8% vs 31.1%）。多因素回归分析证实裸金属支架组是支架内再狭窄的独立危险因素。此外，对侧椎动脉狭窄也是一个重要的危险因素。结论对于药物控制不佳的症状性椎动脉狭窄患者，支架植入术是一种安全有效的治疗方法，药物洗脱支架可显著降低支架内再狭窄的发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neuroscience 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

402

审稿时长

40 days

期刊介绍： This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology. The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.