Crystal Shape Factors of Form I Paracetamol

IF 3.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Crystal Growth & Design Pub Date : 2025-04-18 DOI:10.1021/acs.cgd.5c0000510.1021/acs.cgd.5c00005

Mayank Vashishtha, Juntao Li, Mahmoud Ranjbar, Srinivas Gadipelli, Paul R Shearing, Gavin Walker and K Vasanth Kumar*,

引用次数: 0

Abstract

In this work, we report the new protocols that are developed to determine the shape factors of Form I paracetamol crystals using a combination of techniques that rely on the state-of-the-art X-ray computed tomography and Morphologi G3. The determined shape factors successfully predicted the crystal growth rate of paracetamol in 2-propanol and the length of the crystals growing in the supersaturated solution.

X-ray computed tomography and optical microscopy can be effectively combined to predict crystal shape factors with reasonable accuracy.

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I型扑热息痛的晶体形状因素

在这项工作中，我们报告了使用依赖于最先进的x射线计算机断层扫描和Morphologi G3的技术组合来确定I型扑热息痛晶体形状因素的新方案。确定的形状因子成功地预测了对乙酰氨基酚在2-丙醇中的晶体生长速率和晶体在过饱和溶液中的生长长度。x射线计算机断层扫描和光学显微镜可以有效地结合，以合理的精度预测晶体形状因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Crystal Growth & Design 化学-材料科学：综合

CiteScore

6.30

自引率

10.50%

发文量

650

审稿时长

1.9 months

期刊介绍： The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials. Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.