New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-05-05 DOI:10.1038/s41531-025-00980-7

Shizhuang Wei, Xiaoyu Song, Yakui Mou, Ting Yang, Yao Wang, Hanrui Wang, Chao Ren, Xicheng Song

引用次数: 0

Abstract

Parkinson’s disease (PD), a prevalent neurodegenerative disorder, is linked to genetics and environment, but its mechanisms remain unclear. Emerging evidence connects purinergic signaling-particularly ATP-sensitive P2X7 receptor (P2X7R)-to PD. P2X7R expression is elevated in PD patients, and its antagonist BBG mitigates 6-OHDA-induced dopaminergic neuron death. This review discusses P2X7R’s structure, neural functions, PD-related mechanisms, and therapeutic potential as a targert.

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P2X7R在帕金森病发病机制和治疗中的新见解

帕金森病（PD）是一种常见的神经退行性疾病，与遗传和环境有关，但其机制尚不清楚。新的证据表明嘌呤能信号-特别是atp敏感的P2X7受体(P2X7R)-与PD有关。P2X7R在PD患者中表达升高，其拮抗剂BBG可减轻6-羟多巴胺诱导的多巴胺能神经元死亡。本文就P2X7R的结构、神经功能、pd相关机制以及作为靶点的治疗潜力进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.