Chemically programmable condensates for gene regulation

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2025-05-06 DOI:10.1038/s41589-025-01912-5

引用次数: 0

Abstract

We developed a ligand-responsive solid-state condensate platform for on-demand spatiotemporal control of gene expression in mammalian cells. In particular, the modular design of the condensates enabled spatiotemporal capture and manipulation of DNA, RNA and protein in engineered nuclear condensate structures as an efficient alternative for regulating gene expression.

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用于基因调控的化学可编程冷凝物

我们开发了一个配体响应的固态冷凝平台，用于按需时空控制哺乳动物细胞中的基因表达。特别是，冷凝物的模块化设计使工程核冷凝物结构中的DNA， RNA和蛋白质的时空捕获和操纵成为调节基因表达的有效替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.