Lin Shi, Yichen Xu, Shiying Fan, Zixiao Yin, Guofan Qin, Jianguo Zhang, Anchao Yang
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引用次数: 0
Abstract
Parkinson’s disease (PD) is associated with disrupted neural activity in the substantia nigra, but its electrophysiological changes remain underexplored. This study investigates the oscillatory patterns of substantia nigra pars reticulata (SNr) in PD, compared to dystonia (DT). Intraoperative recordings of the SNr were obtained from 20 PD and 16 DT patients during DBS surgery. Spectral power, neuronal firing rate, beta burst dynamics, and correlation analysis of the SNr signal were analyzed. PD patients exhibited increased alpha and beta power, elevated firing rates, and reduced aperiodic exponent values in SNr compared to DT. PD beta bursts showed prolonged durations and fewer short bursts. Beta power negatively correlated with motor symptom improvement rates in PD but not in DT patients. These findings highlight pathological beta power in SNr of PD, which indicates that SNr-DBS may offer a future therapeutic avenue for PD.
期刊介绍：
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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