Highly Compatible Nanocomposite-Based Bacterial Cellulose Doped With Dopamine and Titanium Dioxide Nanoparticles: Study the Effect of Mode of Addition, Characterization, Antibacterial, and Wound Healing Efficiencies

IF 3.2 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biopolymers Pub Date : 2025-05-06 DOI:10.1002/bip.70025

Fatma El. Zahraa M. Abdelhaq, Mohamed S. Hasanin, Mohamed O. Abdel-Monem, Nouran M. Abd El-Razek, Sawsan Dacrory, Ghada E. Dawwam

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Abstract

Microbial resistance is an expenditure for a country's economy as a whole as well as its health systems. Metal oxide nanoparticles play a role in overcoming microbial resistance to antibiotics. Bacterial cellulose (BC) is a biopolymer that is friendly to the environment and has a wide range of economic uses, particularly in biomedicine. This work deals with the formulation of BC-doped titanium dioxide nanoparticles (TiO₂NPs) and polydopamine (DOP), which are presented with antimicrobial activity. Additionally, the mode of addition of the doped materials was studied using physicochemical analysis, including Fourier transform infrared spectroscopy (FTIR) and x-ray diffraction (XRD). Moreover, the topographical study used scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX). The antimicrobial activity was studied and showed the efficiency of the BC/DOP/TiO₂NP composite against Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, Escherichia coli) strains. Additionally, the wound healing was examined on rats that had been purposely wounded. The results observed that the mode of addition contributed to the molecular structure of the formulated BC-doped samples according to the physicochemical and topographical analysis. Moreover, the BC/DOP/TiO₂NP composite enhanced wound healing for about 95% closure by Day 14 compared to 50% in the control group. Based on the results, we can suggest BC/DOP/TiO₂NP as an excellent candidate for wound dressings.

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掺杂多巴胺和二氧化钛纳米颗粒的高相容性纳米复合细菌纤维素：研究添加方式、表征、抗菌和伤口愈合效率的影响

微生物耐药性是一个国家整体经济及其卫生系统的支出。金属氧化物纳米颗粒在克服微生物对抗生素的耐药性方面发挥着重要作用。细菌纤维素（BC）是一种对环境友好的生物聚合物，具有广泛的经济用途，特别是在生物医学方面。本文研究了bc掺杂二氧化钛纳米颗粒（TiO2NPs）和聚多巴胺（DOP）的制备方法，这些纳米颗粒具有抗菌活性。此外，利用傅里叶红外光谱（FTIR）和x射线衍射（XRD）等理化分析方法研究了掺杂材料的添加方式。此外，利用扫描电子显微镜（SEM）和能量色散x射线（EDX）进行了地形研究。对BC/DOP/ tio2 - np复合菌对革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（铜绿假单胞菌、大肠杆菌）的抑菌活性进行了研究。此外，对故意伤害的大鼠进行伤口愈合检查。通过理化和形貌分析发现，添加方式对bc掺杂样品的分子结构有一定影响。此外，到第14天，BC/DOP/ tio2 - np复合材料使伤口愈合率提高了95%，而对照组为50%。基于这些结果，我们可以建议BC/DOP/TiO2NP作为伤口敷料的理想候选材料。

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来源期刊

Biopolymers 生物-生化与分子生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Founded in 1963, Biopolymers publishes strictly peer-reviewed papers examining naturally occurring and synthetic biological macromolecules. By including experimental and theoretical studies on the fundamental behaviour as well as applications of biopolymers, the journal serves the interdisciplinary biochemical, biophysical, biomaterials and biomedical research communities.