Impact of race, ethnicity, and human immunodeficiency virus status on anal high-risk HPV subtypes: Preliminary insights from a diverse urban population

IF 2.6 3区医学 Q3 ONCOLOGY

Cancer Cytopathology Pub Date : 2025-05-06 DOI:10.1002/cncy.70020

Nikka Khorsandi MD, MPH, Poonam Vohra MD, Peyman Samghabadi MD, Carlo De La Sancha Verduzco MD, Dominic Lung Ct(Ascp), Freddy Chou MS, Steven R. Long MD

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Abstract

Introduction

Racial differences have been identified in the distribution of cervical high-risk human papillomavirus (hrHPV) subtypes; however, there is limited understanding of hrHPV subtypes in anal specimens based on patient race/ethnicity. This knowledge gap limits possible vaccination and/or treatment efforts and may not provide optimal coverage in diverse populations.

Materials and Methods

This preliminary study evaluates anal hrHPV subtype distribution and cytological outcomes in a diverse population accessing care at a large, urban, publicly funded hospital over a 2-year period. The primary objectives were to analyze anal hrHPV subtypes and associated cytologic diagnoses, focusing on disparities among demographic groups, including racial and ethnic diversity, and among individuals living with human immunodeficiency virus (HIV).

Results

Ninety-two patients were identified with a predominance of male (87%) and gay-identifying (50%) individuals and a significant representation from Hispanic/Latinx (36%) and White (36%) backgrounds. A majority (88%) were living with HIV, and only a small fraction (7%) had received HPV vaccination. The most common hrHPV subtypes identified were non-16 and 18 hrHPV subtypes (46%). No significant differences were identified in distribution of HPV subtypes among different races/ethnicities or between sexual and gender minorities and heterosexual, cisgender-identifying individuals. However, individuals with HIV were more likely to have atypical cytologic diagnoses and non-16/18 HPV subtypes.

Conclusions

The findings underscore the prevalence of non-16/18 hrHPV subtypes in a racially and ethnically diverse urban population, particularly among individuals living with HIV. The study highlights the need for expanded HPV subtype surveillance and vaccine development to ensure equitable prevention strategies across diverse populations.

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种族、民族和人类免疫缺陷病毒状态对肛门高危HPV亚型的影响：来自不同城市人口的初步见解

宫颈高危人乳头瘤病毒（hrHPV）亚型的分布已经确定了种族差异；然而，基于患者种族/民族对肛门标本中hrHPV亚型的了解有限。这种知识差距限制了可能的疫苗接种和/或治疗工作，并且可能无法在不同人群中提供最佳覆盖率。材料和方法本初步研究评估了在大型城市公立医院就诊的不同人群的肛门hrHPV亚型分布和细胞学结果，为期2年。主要目的是分析肛门hrHPV亚型和相关细胞学诊断，重点关注人口统计学群体之间的差异，包括种族和民族多样性，以及人类免疫缺陷病毒（HIV）感染者之间的差异。结果92例患者以男性（87%）和同性恋（50%）为主，西班牙裔/拉丁裔（36%）和白人（36%）背景占显著比例。大多数人（88%）感染了艾滋病毒，只有一小部分人（7%）接种了HPV疫苗。最常见的hrHPV亚型是非16型和18型（46%）。HPV亚型在不同种族/民族之间或性少数和性别少数群体与异性恋、顺性别认同个体之间的分布未发现显著差异。然而，艾滋病毒感染者更有可能有非典型细胞学诊断和非16/18 HPV亚型。结论：研究结果强调了非16/18 hrHPV亚型在不同种族和民族的城市人群中的流行，特别是在艾滋病毒感染者中。该研究强调需要扩大HPV亚型监测和疫苗开发，以确保在不同人群中采取公平的预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cytopathology 医学-病理学

CiteScore

7.00

自引率

17.60%

发文量

130

审稿时长

1 months

期刊介绍： Cancer Cytopathology provides a unique forum for interaction and dissemination of original research and educational information relevant to the practice of cytopathology and its related oncologic disciplines. The journal strives to have a positive effect on cancer prevention, early detection, diagnosis, and cure by the publication of high-quality content. The mission of Cancer Cytopathology is to present and inform readers of new applications, technological advances, cutting-edge research, novel applications of molecular techniques, and relevant review articles related to cytopathology.