Blood pressure changes in patients after Minoxidil microinfusion to treat female pattern alopecia: analysis of a randomized, single blinded, placebo controlled clinical trial

IF 1.8 4区医学 Q3 DERMATOLOGY

Archives of Dermatological Research Pub Date : 2025-05-06 DOI:10.1007/s00403-025-04247-2

Flávia Machado Alves Basilio, Fabiane Mulinari-Brenner, Betina Werner, Nubia Vedovatto de Macedo

{"title":"Blood pressure changes in patients after Minoxidil microinfusion to treat female pattern alopecia: analysis of a randomized, single blinded, placebo controlled clinical trial","authors":"Flávia Machado Alves Basilio, Fabiane Mulinari-Brenner, Betina Werner, Nubia Vedovatto de Macedo","doi":"10.1007/s00403-025-04247-2","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Microinfusion is a superficial microneedling procedure that infuses medications into the surface of the dermis through disposable needles attached to tattoo equipment. Various medications can be microinfused; minoxidil is frequently utilized as an adjuvant treatment for androgenetic alopecia, but little data is available on its systemic effects when administered via this technique.</p><h3>Objective</h3><p>To compare blood pressure readings before and after microinfusion of minoxidil in the scalp to assess this drug’s systemic effects when applied using this technique.</p><h3>Methods</h3><p>This randomized, controlled, blinded study was conducted with 24 patients divided into 2 groups to compare microinfusion with 0.5% minoxidil and saline solution (control group). Participants underwent 3 sessions at monthly intervals, and their blood pressure was measured before and after each microinfusion procedure.</p><h3>Results</h3><p>A statistically significant reduction in diastolic blood pressure was observed after the procedure in the minoxidil group (<i>p</i> = 0.037). In the control group, a statistically significant increase in systolic blood pressure was found (<i>p</i> = 0.013).</p><h3>Conclusion</h3><p>Reduction of diastolic blood pressure in the minoxidil group proved dermal delivery and systemic absorption of the medication after scalp microinfusion. Increased systolic pressure in the control group may be related to pain during the procedure.</p><h3>Brazilian registry of clinical trials</h3><p>(ReBEC): RBR-368fdb3; Date of registration: April, 11th, 2024 (retrospectively registered).</p></div>","PeriodicalId":8203,"journal":{"name":"Archives of Dermatological Research","volume":"317 1","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Dermatological Research","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00403-025-04247-2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Microinfusion is a superficial microneedling procedure that infuses medications into the surface of the dermis through disposable needles attached to tattoo equipment. Various medications can be microinfused; minoxidil is frequently utilized as an adjuvant treatment for androgenetic alopecia, but little data is available on its systemic effects when administered via this technique.

Objective

To compare blood pressure readings before and after microinfusion of minoxidil in the scalp to assess this drug’s systemic effects when applied using this technique.

Methods

This randomized, controlled, blinded study was conducted with 24 patients divided into 2 groups to compare microinfusion with 0.5% minoxidil and saline solution (control group). Participants underwent 3 sessions at monthly intervals, and their blood pressure was measured before and after each microinfusion procedure.

Results

A statistically significant reduction in diastolic blood pressure was observed after the procedure in the minoxidil group (p = 0.037). In the control group, a statistically significant increase in systolic blood pressure was found (p = 0.013).

Conclusion

Reduction of diastolic blood pressure in the minoxidil group proved dermal delivery and systemic absorption of the medication after scalp microinfusion. Increased systolic pressure in the control group may be related to pain during the procedure.

Brazilian registry of clinical trials

(ReBEC): RBR-368fdb3; Date of registration: April, 11th, 2024 (retrospectively registered).

查看原文本刊更多论文

米诺地尔微量输注治疗女性型脱发后患者血压变化：一项随机、单盲、安慰剂对照临床试验分析

背景：微注射是一种浅表微针注射过程，通过连接在纹身设备上的一次性针头将药物注入真皮表面。各种药物可以微注射；米诺地尔经常被用作雄激素性脱发的辅助治疗，但很少有数据表明，当通过这种技术给药时，它的全身效应。目的比较头皮微量输注米诺地尔前后的血压读数，评价米诺地尔在应用该技术时的全身效应。方法将24例患者随机、对照、盲法分为2组，比较微量输注0.5%米诺地尔和生理盐水（对照组）的差异。参与者每个月进行3次治疗，并在每次微量输注过程前后测量血压。结果米诺地尔组术后舒张压降低有统计学意义（p = 0.037）。对照组患者收缩压升高，差异有统计学意义（p = 0.013）。结论米诺地尔组患者经头皮微滴给药后，舒张压明显降低。对照组收缩压升高可能与手术过程中的疼痛有关。巴西临床试验登记处（ReBEC）： RBR-368fdb3；注册日期：2024年4月11日（追溯注册）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archives of Dermatological Research 医学-皮肤病学

CiteScore

4.10

自引率

3.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.