The distribution of gonadotropin-inhibitory hormone (GnIH) and its receptor in zebra finch (Taeniopygia guttata) spinal cord

IF 1.7 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

General and comparative endocrinology Pub Date : 2025-04-17 DOI:10.1016/j.ygcen.2025.114733

Devon Comito, George E. Bentley

{"title":"The distribution of gonadotropin-inhibitory hormone (GnIH) and its receptor in zebra finch (Taeniopygia guttata) spinal cord","authors":"Devon Comito, George E. Bentley","doi":"10.1016/j.ygcen.2025.114733","DOIUrl":null,"url":null,"abstract":"<div><div>Gonadotropin-inhibitory hormone (GnIH) is a neuropeptide that typically acts in the hypothalamic-pituitary–gonadal (HPG) axis to regulate reproductive activity and sociosexual behaviors. GnIH is synthesized in the brain and in the gonads, where it can act via its cognate receptor. However, immunohistological evidence in songbirds also shows GnIH projections towards the brainstem. We propose that GnIH can act within the spinal cord and possibly on a variety of organs to induce rapid behavioral and physiological changes in response to environmental cues. Here we used immunohistochemistry (IHC) and PCR to document GnIH and its receptor in zebra finch (<em>Taeniopygia guttata</em>) spinal cord. We found immunoreactive GnIH throughout the length of the spine, predominantly in the central gray matter of the cervical region. mRNA for the GnIH precursor gene and receptor gene was also present throughout the length of the spinal cord. This is the first evidence of GnIH in the avian spinal cord. These results hint at a novel pathway for neuropeptide action in vertebrates.</div></div>","PeriodicalId":12582,"journal":{"name":"General and comparative endocrinology","volume":"368 ","pages":"Article 114733"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General and comparative endocrinology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0016648025000735","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Gonadotropin-inhibitory hormone (GnIH) is a neuropeptide that typically acts in the hypothalamic-pituitary–gonadal (HPG) axis to regulate reproductive activity and sociosexual behaviors. GnIH is synthesized in the brain and in the gonads, where it can act via its cognate receptor. However, immunohistological evidence in songbirds also shows GnIH projections towards the brainstem. We propose that GnIH can act within the spinal cord and possibly on a variety of organs to induce rapid behavioral and physiological changes in response to environmental cues. Here we used immunohistochemistry (IHC) and PCR to document GnIH and its receptor in zebra finch (Taeniopygia guttata) spinal cord. We found immunoreactive GnIH throughout the length of the spine, predominantly in the central gray matter of the cervical region. mRNA for the GnIH precursor gene and receptor gene was also present throughout the length of the spinal cord. This is the first evidence of GnIH in the avian spinal cord. These results hint at a novel pathway for neuropeptide action in vertebrates.

Abstract Image

查看原文本刊更多论文

促性腺激素抑制激素（GnIH）及其受体在斑胸草雀脊髓中的分布

促性腺激素抑制激素（GnIH）是一种神经肽，通常作用于下丘脑-垂体-性腺（HPG）轴，调节生殖活动和社会性行为。GnIH在大脑和性腺中合成，在那里它可以通过其同源受体起作用。然而，鸣禽的免疫组织学证据也显示GnIH向脑干的投射。我们认为GnIH可以在脊髓内起作用，也可能作用于多种器官，以诱导对环境线索的快速行为和生理变化。本研究采用免疫组织化学（IHC）和PCR技术对斑胸草雀（Taeniopygia guttata）脊髓中的GnIH及其受体进行了检测。我们发现免疫反应性GnIH贯穿整个脊柱，主要在颈椎区域的中央灰质。GnIH前体基因和受体基因的mRNA也存在于整个脊髓中。这是鸟类脊髓中GnIH的第一个证据。这些结果暗示了神经肽在脊椎动物中作用的新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

General and comparative endocrinology 医学-内分泌学与代谢

CiteScore

5.60

自引率

7.40%

发文量

120

审稿时长

2 months

期刊介绍： General and Comparative Endocrinology publishes articles concerned with the many complexities of vertebrate and invertebrate endocrine systems at the sub-molecular, molecular, cellular and organismal levels of analysis.