Antifungal susceptibility of a collection of Aspergillus fumigatus strains isolated from patients with invasive pulmonary aspergillosis and COVID-19 associated aspergillosis

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-05-01 DOI:10.1016/j.diagmicrobio.2025.116884

Andrea Liberatore , Giulia Lombardi , Donatella Lombardo , Tiziana Lazzarotto , Claudio Foschi , Simone Ambretti

引用次数: 0

Abstract

We assessed the antifungal susceptibility of 86 Aspergillus fumigatus strains by a phenotypic test. Azole sensitivity was compared to a molecular test detecting cyp51A mutations. Azole resistance was quite limited, whereas strains from COVID-19 patients showed higher amphotericin B MICs. The molecular test showed a 100 %-agreement with the phenotypic assay.

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侵袭性肺曲霉病和COVID-19相关曲霉病患者分离的烟曲霉菌株的抗真菌敏感性

我们通过表型试验评估了86株烟曲霉菌株的抗真菌敏感性。将唑敏感性与检测cyp51A突变的分子试验进行比较。对唑的耐药性相当有限，而来自COVID-19患者的菌株则表现出较高的两性霉素B mic。分子检测结果与表型检测结果100%一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.