Evolución de prescripción antibiótica en Atención Primaria según indicadores del PRAN (Plan Nacional frente a la Resistencia a los Antibióticos)

IF 1.5 4区医学 Q2 PEDIATRICS

Anales de pediatria Pub Date : 2025-05-01 DOI:10.1016/j.anpedi.2025.503840

Carlos Marcilla Vázquez , Juan Ríos Laorden , Ángeles Lloret Callejo , Francisco Tejada Cifuentes , María José Tirado Peláez , Ignacio Párraga-Martínez

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Abstract

Introduction

Spain is the fourth European country with the highest antibiotic consumption at the community level, and children aged 0 to 4 years are one of the age groups with the highest consumption. The aim of our study was to analyze the evolution of antibiotic prescribing in the paediatric catchment population of a primary care area in Spain according to the indicators established in the National Plan against Antibiotic Resistance (PRAN) over 10 years (2014-2023) and to assess the impact of the COVID-19 pandemic by comparing the 2020-2021 period with the preceding and subsequent periods (2014-2019 and 2022-2023).

Material and methods

Retrospective observational study of the prescribing of antibiotics for systemic use (J01 group of the Anatomical Therapeutic Chemical Classification) in paediatric patients (0-14 years) covered by the primary care system of the Albacete health care administration between 2014 and 2023.

Results

The mean antibiotic prescription was 16.90 defined daily doses (DDD) per 1000 inhabitants per day and 12.10 DOT (days of therapy). The corresponding values in the prepandemic period (2014-2019) were 19.32 DDD/1000 inhabitants/day and 13.92 DOT, which decreased to 8.30 DDD/1000 inhabitants/day and 6.05 DOT during the pandemic (2020-2021) and then increased to 18.05 DDD/1000 inhabitants/day and 12.40 DOT in the pospandemic period (2022-2023). There was an improvement in appropriate prescribing after the COVID-19 pandemic, with a reduction in the consumption of amoxicillin-clavulanic acid and greater consumption of penicillin and amoxicillin during prepandemic and pandemic years (P < .05).

Conclusions

Throughout the study period, there was improvement in the consumption indicators established in the PRAN, with an increase in the use of beta-lactamase sensitive penicillins and amoxicillin and a reduction in the use of amoxicillin-clavulanic acid.

Abstract Image

查看原文本刊更多论文

根据国家抗菌素耐药性计划的指标，初级保健中抗生素处方的变化情况

西班牙是欧洲第四大社区抗生素消费量最高的国家，0 - 4岁儿童是消费量最高的年龄组之一。本研究的目的是根据国家抗抗生素耐药性计划（PRAN）中确定的10年（2014-2023年）指标，分析西班牙一个初级保健区儿科集水区抗生素处方的演变情况，并通过将2020-2021年与之前和之后的时期（2014-2019年和2022-2023年）进行比较，评估COVID-19大流行的影响。材料和方法回顾性观察研究2014年至2023年Albacete卫生保健管理局初级保健系统覆盖的0-14岁儿科患者全身使用抗生素（解剖治疗化学分类J01组）的情况。结果平均抗生素处方为16.90限定日剂量(DDD) / 1000人/天，12.10治疗日（DOT）。流行前（2014-2019年）相应值为19.32 DDD/1000居民/日和13.92 DOT，流行期间（2020-2021年）下降至8.30 DDD/1000居民/日和6.05 DOT，流行后（2022-2023年）上升至18.05 DDD/1000居民/日和12.40 DOT。在2019冠状病毒病大流行后，适当处方有所改善，在大流行前和大流行年份，阿莫西林-克拉维酸的消费量减少，青霉素和阿莫西林的消费量增加(P <；. 05)。结论在整个研究期间，PRAN中建立的消费指标有所改善，β -内酰胺酶敏感青霉素和阿莫西林的使用增加，阿莫西林-克拉维酸的使用减少。

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来源期刊

Anales de pediatria 医学-小儿科

CiteScore

2.10

自引率

4.80%

发文量

155

审稿时长

44 days

期刊介绍： La Asociación Española de Pediatría tiene como uno de sus objetivos principales la difusión de información científica rigurosa y actualizada sobre las distintas áreas de la pediatría. Anales de Pediatría es el Órgano de Expresión Científica de la Asociación y constituye el vehículo a través del cual se comunican los asociados. Publica trabajos originales sobre investigación clínica en pediatría procedentes de España y países latinoamericanos, así como artículos de revisión elaborados por los mejores profesionales de cada especialidad, las comunicaciones del congreso anual y los libros de actas de la Asociación, y guías de actuación elaboradas por las diferentes Sociedades/Secciones Especializadas integradas en la Asociación Española de Pediatría.