Association between frailty and inflammatory cytokines in patients with multiple sclerosis: a case-control study

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-05-06 DOI:10.1016/j.cyto.2025.156945

Shucheng Xing, Xue Li, Chen Chen

{"title":"Association between frailty and inflammatory cytokines in patients with multiple sclerosis: a case-control study","authors":"Shucheng Xing, Xue Li, Chen Chen","doi":"10.1016/j.cyto.2025.156945","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Frailty is a common symptom in Multiple Sclerosis (MS), yet its precise mechanism remains elusive, and the clinical implications of frailty in MS are uncertain. Moreover, inflammation is closely linked to frailty. This study aims to assess serum cytokine levels in individuals with MS and explore their correlation with frailty.</div></div><div><h3>Methods</h3><div>A case-control study included 83 primary MS patients and 100 healthy individuals undergoing health check-ups. Serum cytokine levels were measured, and MS severity was determined using the Expanded Disability Status Scale (EDSS) score. Additionally, a comprehensive frailty index (FI) was calculated based on health deficits from various domains following standardized procedures.</div></div><div><h3>Results</h3><div>Serum IL-6 and TNF-α levels were significantly higher in the frail group than in the non-frail group, with a statistically significant difference (<em>P</em> < 0.05). After adjusting for disease duration, sex, age, BMI, SBP, and DBP, serum IL-6 independently correlated with frailty in MS patients (OR = 1.46; 95 % CI = 1.02–1.93; <em>P</em> = 0.003). Moreover, increased serum IL-6 levels were associated positively with the frailty index (β = 0.123, <em>P</em> = 0.008).</div></div><div><h3>Conclusion</h3><div>Our initial findings suggest elevated levels of pro-inflammatory cytokines in MS patients with frailty, with IL-6 showing a positive correlation with frail indices. These results underscore the potential impact of inflammatory responses on frailty development in MS.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"191 ","pages":"Article 156945"},"PeriodicalIF":3.7000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytokine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1043466625000924","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Frailty is a common symptom in Multiple Sclerosis (MS), yet its precise mechanism remains elusive, and the clinical implications of frailty in MS are uncertain. Moreover, inflammation is closely linked to frailty. This study aims to assess serum cytokine levels in individuals with MS and explore their correlation with frailty.

Methods

A case-control study included 83 primary MS patients and 100 healthy individuals undergoing health check-ups. Serum cytokine levels were measured, and MS severity was determined using the Expanded Disability Status Scale (EDSS) score. Additionally, a comprehensive frailty index (FI) was calculated based on health deficits from various domains following standardized procedures.

Results

Serum IL-6 and TNF-α levels were significantly higher in the frail group than in the non-frail group, with a statistically significant difference (P < 0.05). After adjusting for disease duration, sex, age, BMI, SBP, and DBP, serum IL-6 independently correlated with frailty in MS patients (OR = 1.46; 95 % CI = 1.02–1.93; P = 0.003). Moreover, increased serum IL-6 levels were associated positively with the frailty index (β = 0.123, P = 0.008).

Conclusion

Our initial findings suggest elevated levels of pro-inflammatory cytokines in MS patients with frailty, with IL-6 showing a positive correlation with frail indices. These results underscore the potential impact of inflammatory responses on frailty development in MS.

查看原文本刊更多论文

多发性硬化症患者虚弱和炎症细胞因子之间的关系：一项病例对照研究

背景：虚弱是多发性硬化症（MS）的常见症状，但其确切机制尚不清楚，MS中虚弱的临床意义也不确定。此外，炎症与身体虚弱密切相关。本研究旨在评估多发性硬化症患者血清细胞因子水平，并探讨其与虚弱的相关性。方法对83例原发多发性硬化症患者和100例健康体检者进行病例对照研究。测量血清细胞因子水平，并使用扩展残疾状态量表（EDSS）评分确定MS严重程度。此外，根据标准化程序，根据各个领域的健康缺陷计算综合虚弱指数（FI）。结果体弱组血清IL-6、TNF-α水平明显高于非体弱组，差异有统计学意义(P <；0.05)。在调整病程、性别、年龄、BMI、收缩压和舒张压后，血清IL-6与MS患者的虚弱独立相关(OR = 1.46；95% ci = 1.02-1.93；p = 0.003)。血清IL-6水平升高与衰弱指数呈正相关（β = 0.123, P = 0.008）。我们的初步研究结果表明，MS虚弱患者的促炎细胞因子水平升高，IL-6与虚弱指标呈正相关。这些结果强调了炎症反应对MS虚弱发展的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.