Role, binding properties, and potential therapeutical use of glycosaminoglycans and mimetics in SARS-CoV-2 infection. In memory of Dr. Robert Linhardt (1953–2025)

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-05-03 DOI:10.1016/j.carbpol.2025.123703

Vitor H. Pomin , Fuming Zhang , Jonathan S. Dordick

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Abstract

Dr. Robert Linhardt was a prolific scientist who paved the way for understanding the key aspects of structure, function, synthesis, mechanisms of action, and potential therapeutic use of glycosaminoglycans (GAGs). His contribution to the field of Glycobiology for over 40 years led to an incredible legacy in terms of mentorship, publication, and research accomplishment. Sorrowfully, he succumbed to a rare case of spinal cancer aggravated by a SARS-CoV-2 infection at the beginning of 2025. Since the COVID-19 pandemic, Dr. Linhardt published approximately 20 groundbreaking scientific articles unraveling the role, mechanism of action, virus binding properties, and potential anti-SARS-CoV-2 use of GAGs. In honor of the extraordinary contribution of Dr. Robert Linhardt in the fields of GAGs and SARS-CoV2, we review herein the main scientific achievements of his set of published works on the topic, after presenting a biography of this renowned glycoscientist.

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糖胺聚糖和模拟物在SARS-CoV-2感染中的作用、结合特性和潜在的治疗用途纪念罗伯特·林哈特博士（1953-2025）

Robert Linhardt博士是一位多产的科学家，他为理解糖胺聚糖（GAGs）的结构、功能、合成、作用机制和潜在治疗用途的关键方面铺平了道路。他对糖生物学领域的贡献超过40年，在指导、出版和研究成就方面留下了令人难以置信的遗产。不幸的是，他在2025年初死于一种罕见的脊髓癌，这种癌症因SARS-CoV-2感染而加重。自COVID-19大流行以来，Linhardt博士发表了大约20篇开创性的科学文章，揭示了gag的作用、作用机制、病毒结合特性以及抗sars - cov -2的潜在用途。为了纪念Robert Linhardt博士在gag和SARS-CoV2领域的杰出贡献，在介绍这位著名糖科学家的传记之后，我们在此回顾他在该主题上发表的一套主要科学成就。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.