From mechanism to applications: Advanced microneedles for clinical medicine

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-05-05 DOI:10.1016/j.bioactmat.2025.04.025

Yuqing Yang , Haifu Sun , Xiao Sun , Yu Wang , Fan Xu , Wenyu Xia , Liang Chen , Manyi Li , Tianke Yang , Yusen Qiao , Dechun Geng

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引用次数: 0

Abstract

Advanced microneedles (MNs) are a series of complex and multifunctional MNs designed for a variety of clinical applications that are not only efficacious but also cost-effective, acceptable, and safe. In light of the potential limitations of conventional drug delivery, including low drug bioavailability and insufficient therapeutic efficiency, as well as the financial burden and discomfort associated with conventional detection, there is a thirst for alternatives. As a novel form of cargo delivery capable of penetrating tissue surface barriers easily, MNs avoid the various risks associated with traditional testing tools, and can achieve precise, on-demand, or continuous drug delivery. It has great potential to become an ideal clinical tool. Herein, an exhaustive review is proposed to summarize the designs and research progress of MNs. First, the designs and fabrication of it are introduced. Next, recent advances of applications in detection and therapy of MNs are systematically classified and discussed. Second, clinical trials of MNs in recent five years and commercial MNs are provided. Furthermore, this review discusses the limitations and challenges of MNs and speculates on their prospective evolution and applications in biomedicine. This review focuses on the future effective utilization of MNs and novel designs of innovative and effective clinical MNs devices.

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从机理到应用：用于临床医学的先进微针

先进微针（MNs）是一系列复杂和多功能的微针，设计用于各种临床应用，不仅有效，而且具有成本效益，可接受和安全。鉴于传统药物递送的潜在局限性，包括药物生物利用度低和治疗效率不足，以及与传统检测相关的经济负担和不适，人们渴望找到替代方法。作为一种能够轻松穿透组织表面屏障的新型药物递送方式，MNs避免了与传统测试工具相关的各种风险，并且可以实现精确、按需或连续的药物递送。它有很大的潜力成为理想的临床工具。本文对纳米粒子的设计和研究进展进行了全面的综述。首先介绍了它的设计和制作。其次，对纳米颗粒的检测和治疗的最新进展进行了系统的分类和讨论。其次，提供了近五年MNs的临床试验和商业化MNs。此外，本文还讨论了纳米粒子的局限性和挑战，并对其未来的发展和在生物医学中的应用进行了展望。本文综述了未来MNs的有效利用以及创新和有效的临床MNs装置的新设计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.