Impact and safety of pregnancy on desmoid fibromatosis management in the era of active surveillance. An international multicenter retrospective observational study

IF 7.6 1区医学 Q1 ONCOLOGY

European Journal of Cancer Pub Date : 2025-04-30 DOI:10.1016/j.ejca.2025.115474

Marco Fiore , Silva Ljevar , Chandraijt Premanand Raut , Giulia Personeni , Mikhael Rabih , Rebecca Gladdy , Kelly Mercier , Megan Sulciner , Enrica Rossi , Dimitri Tzanis , Harini Suraweera , Chiara Colombo , Marianna Coppola , Sylvie Bonvalot , Sara Iadecola , Catherine Sarre-Lazcano , Costanza Figura , Daniela Salvatore , Rosalba Miceli , Alessandro Gronchi

{"title":"Impact and safety of pregnancy on desmoid fibromatosis management in the era of active surveillance. An international multicenter retrospective observational study","authors":"Marco Fiore , Silva Ljevar , Chandraijt Premanand Raut , Giulia Personeni , Mikhael Rabih , Rebecca Gladdy , Kelly Mercier , Megan Sulciner , Enrica Rossi , Dimitri Tzanis , Harini Suraweera , Chiara Colombo , Marianna Coppola , Sylvie Bonvalot , Sara Iadecola , Catherine Sarre-Lazcano , Costanza Figura , Daniela Salvatore , Rosalba Miceli , Alessandro Gronchi","doi":"10.1016/j.ejca.2025.115474","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate desmoid fibromatosis (DF) progression and obstetric outcomes during and after pregnancy, providing evidence to inform clinical decision-making and counseling.</div></div><div><h3>Methods</h3><div>This international, multicenter, retrospective observational study included data from 157 women with DF, contributing 177 pregnancies. Women were classified into three groups: DF diagnosed during pregnancy (Group A), pregnancy occurring after the diagnosis of DF (Group B: DF in situ during pregnancy), or pregnancy in previously resected DF (Group C). Logistic regression and tumor size trend analyses were conducted.</div></div><div><h3>Results</h3><div>Among 177 pregnancies, Group A exhibited the highest rates of DF progression (68.7 % during pregnancy, 40.6 % postpartum), while Groups B and C had lower progression rates (9.5 % during pregnancy, 8.3 % postpartum). Active treatment was required in 5.6 % of cases. Spontaneous regression occurred in 23.7 % of pregnancies, particularly following progression. Obstetric complications were comparable to those in the general population.</div></div><div><h3>Conclusion</h3><div>Pregnancy is generally safe for women with DF, particularly after prolonged disease stability. Individualized counseling is essential for managing risks of progression and recurrence, supporting informed fertility decisions. Referral to specialized centers is recommended to optimize DF management during family planning and pregnancy.</div></div>","PeriodicalId":11980,"journal":{"name":"European Journal of Cancer","volume":"222 ","pages":"Article 115474"},"PeriodicalIF":7.6000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959804925002552","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

To evaluate desmoid fibromatosis (DF) progression and obstetric outcomes during and after pregnancy, providing evidence to inform clinical decision-making and counseling.

Methods

This international, multicenter, retrospective observational study included data from 157 women with DF, contributing 177 pregnancies. Women were classified into three groups: DF diagnosed during pregnancy (Group A), pregnancy occurring after the diagnosis of DF (Group B: DF in situ during pregnancy), or pregnancy in previously resected DF (Group C). Logistic regression and tumor size trend analyses were conducted.

Results

Among 177 pregnancies, Group A exhibited the highest rates of DF progression (68.7 % during pregnancy, 40.6 % postpartum), while Groups B and C had lower progression rates (9.5 % during pregnancy, 8.3 % postpartum). Active treatment was required in 5.6 % of cases. Spontaneous regression occurred in 23.7 % of pregnancies, particularly following progression. Obstetric complications were comparable to those in the general population.

Conclusion

Pregnancy is generally safe for women with DF, particularly after prolonged disease stability. Individualized counseling is essential for managing risks of progression and recurrence, supporting informed fertility decisions. Referral to specialized centers is recommended to optimize DF management during family planning and pregnancy.

查看原文本刊更多论文

主动监测时代妊娠对硬纤维瘤病治疗的影响及安全性。一项国际多中心回顾性观察研究

目的评价硬纤维瘤病（DF）在妊娠期间和妊娠后的进展和产科结局，为临床决策和咨询提供依据。方法：本研究是一项国际性、多中心、回顾性观察性研究，包括157例DF妇女，其中177例妊娠。妇女被分为三组：妊娠期间诊断的DF （A组），DF诊断后发生的妊娠（B组：妊娠期间原位DF），或先前切除DF的妊娠（C组）。进行Logistic回归和肿瘤大小趋势分析。结果177例妊娠中，A组DF进展率最高（妊娠期间为68.7% %，产后为40.6% %），B、C组DF进展率较低（妊娠期间为9.5% %，产后为8.3 %）。5.6%（ %）的病例需要积极治疗。23.7% %的妊娠发生自然退化，特别是在妊娠进展后。产科并发症与一般人群相当。结论DF患者妊娠通常是安全的，特别是在疾病长期稳定后。个性化咨询对于控制进展和复发的风险，支持明智的生育决策至关重要。建议转诊到专门的中心，以优化计划生育和怀孕期间的DF管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Cancer 医学-肿瘤学

CiteScore

11.50

自引率

4.80%

发文量

953

审稿时长

23 days

期刊介绍： The European Journal of Cancer (EJC) serves as a comprehensive platform integrating preclinical, digital, translational, and clinical research across the spectrum of cancer. From epidemiology, carcinogenesis, and biology to groundbreaking innovations in cancer treatment and patient care, the journal covers a wide array of topics. We publish original research, reviews, previews, editorial comments, and correspondence, fostering dialogue and advancement in the fight against cancer. Join us in our mission to drive progress and improve outcomes in cancer research and patient care.