Sharpening the lens of NMR spectroscopy to study large proteins

IF 19.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature chemistry Pub Date : 2025-05-05 DOI:10.1038/s41557-025-01817-9

Yun Huang, David Eliezer

引用次数: 0

Abstract

NMR spectroscopy is a critical tool for linking protein structure, dynamics and interactions to protein function, but is challenging to apply to high-molecular-weight proteins. The chemical synthesis of an NMR probe combines the advantages of four different nuclei, 1H, 2H, 13C and 19F, to achieve optimal resolution for these larger systems.

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锐化核磁共振光谱的透镜来研究大的蛋白质

核磁共振波谱是将蛋白质结构、动力学和相互作用与蛋白质功能联系起来的关键工具，但将其应用于高分子量蛋白质具有挑战性。化学合成的核磁共振探针结合了四种不同核的优点，1H, 2H， 13C和19F，以实现这些较大系统的最佳分辨率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature chemistry 化学-化学综合

CiteScore

29.60

自引率

1.40%

发文量

226

审稿时长

1.7 months

期刊介绍： Nature Chemistry is a monthly journal that publishes groundbreaking and significant research in all areas of chemistry. It covers traditional subjects such as analytical, inorganic, organic, and physical chemistry, as well as a wide range of other topics including catalysis, computational and theoretical chemistry, and environmental chemistry. The journal also features interdisciplinary research at the interface of chemistry with biology, materials science, nanotechnology, and physics. Manuscripts detailing such multidisciplinary work are encouraged, as long as the central theme pertains to chemistry. Aside from primary research, Nature Chemistry publishes review articles, news and views, research highlights from other journals, commentaries, book reviews, correspondence, and analysis of the broader chemical landscape. It also addresses crucial issues related to education, funding, policy, intellectual property, and the societal impact of chemistry. Nature Chemistry is dedicated to ensuring the highest standards of original research through a fair and rigorous review process. It offers authors maximum visibility for their papers, access to a broad readership, exceptional copy editing and production standards, rapid publication, and independence from academic societies and other vested interests. Overall, Nature Chemistry aims to be the authoritative voice of the global chemical community.