Gout and NLRP3 inflammasome biology

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2025-05-05 DOI:10.1002/art.43215

Raewyn Poulsen, Nicola Dalbeth

引用次数: 0

Abstract

This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilisation, and self-resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal-induced inflammation is reviewed in detail. Treatment strategies for gout are outlined in the context of the mechanisms of NLRP3 inflammasome-mediated acute inflammation.

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痛风与NLRP3炎性体生物学

这篇综述描述了痛风背景下急性炎症的三个阶段：起始、白细胞动员和自我消退。本文介绍了一个典型的痛风耀斑病例。本文对NLRP3炎症小体在急性尿酸钠晶体性炎症中的作用进行了详细的综述。痛风的治疗策略概述在NLRP3炎症小体介导的急性炎症机制的背景下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.