A Strategy for Increasing Singlet Oxygen Quantum Yield for Water-Soluble Distyryl-BODIPY Derivative

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2025-05-04 DOI:10.1002/aoc.70184

Ceren Can Karanlık, Gürkan Karanlık, Ali Erdoğmuş

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引用次数: 0

Abstract

The combined use of synergistic therapies in photodynamic therapy has recently gained significance for achieving more effective outcomes. In recent years, ultrasound-assisted PDT applications have begun to be investigated in phthalocyanine and BODIPY derivative compounds. BODIPY compounds stand out with their adjustable photophysical and photochemical properties, chemical purity, and singlet oxygen generation capacity. Enhancing singlet oxygen production by BODIPY through the application of ultrasound appears to be a promising avenue for advancing this treatment method. In this context, exploring the potential of sonophotochemical properties is of particular interest. The limited SPDT applications of BODIPY derivative compounds increase the importance of investigating the sonophotochemical properties of the compounds. Therefore, a new water-soluble distyryl-type BODIPY fluorophore having phenyl ring substituted with a 4-dibenzothienyl group at meso-position and iodines as heavy atom at 2- and 6-positions has been synthesized successfully. The singlet oxygen production capacities of all intermediates and target product were evaluated by both photochemically and sonophotochemically. It was noticed that the singlet oxygen quantum yield increased remarkably with the combined use of light and ultrasound in the excitation of the compounds.

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提高水溶性二酰基二吡啶衍生物单线态氧量子产率的策略

在光动力治疗中联合使用协同疗法对于获得更有效的结果具有重要意义。近年来，超声辅助PDT在酞菁和BODIPY衍生物中的应用已经开始研究。BODIPY化合物以其可调节的光物理和光化学性质，化学纯度和单线态氧生成能力而脱颖而出。通过超声的应用来提高BODIPY的单线态产氧似乎是推进这种治疗方法的一个有前途的途径。在这种情况下，探索声光化学性质的潜力是特别感兴趣的。BODIPY衍生物的有限SPDT应用增加了研究其声光化学性质的重要性。因此，成功合成了一种新的水溶性二苯基型BODIPY荧光基团，在中间位置苯基环被4-二苯并噻吩基取代，在2位和6位重原子为碘。利用光化学和声光化学方法对中间体和靶产物的单线态产氧能力进行了评价。我们注意到，在光和超声的联合激发下，化合物的单线态氧量子产率显著提高。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.