Research Into the Differences and Clinical Diagnostic Importance of Different Ct Values in COVID-19 Patients of Different Age, Albumin, Lactate Dehydrogenase, and Lymphocyte Percentages

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-05-05 DOI:10.1155/ijcp/8818243

Han Su, Li Xu, Fulu Chu, Guolin Bao, Shiyu Zhao, Shan Ding, Yiqing Liu

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Abstract

Introduction: This study aims to investigate the differences and clinical diagnostic importance of different Ct (cycle threshold) values in COVID-19 patients of different age, albumin, lactate dehydrogenase (LDH), and lymphocyte percentage (LYM%).

Methods: A total of 2836 patients confirmed with COVID-19 in our Hospital between January 1 and May 30, 2023 were divided into the high Ct value (34.21–40.00), the medium Ct value (26.51–34.21), and the low Ct value groups (0.00–26.51) using the interquartile method against the negative (control group).

Results: Significant differences were observed in clinical indicators between the middle Ct group and the control group; however, no significant differences were noted between the middle and high Ct groups. In the high Ct group, notable disparities in albumin and LDH were found compared to the control. The low Ct group exhibited significant differences from the high Ct group regarding age and LYM%. Furthermore, age was significantly different within the low Ct group when compared to the middle one. Nonetheless, no significant variations in LDH were detected between the low Ct group and the control.

Conclusion: People over 59 years old are at an elevated risk for higher viral loads and increased susceptibility to COVID-19 infection. Albumin and LYM% serve as protective factors against this disease. Age, albumin, and LYM% demonstrate favorable predictive values for distinguishing individuals within the low Ct category from other groups.

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不同年龄、白蛋白、乳酸脱氢酶、淋巴细胞百分比的COVID-19患者不同Ct值的差异及临床诊断意义研究

前言：本研究旨在探讨不同年龄、白蛋白、乳酸脱氢酶（LDH）、淋巴细胞百分比（LYM%）在COVID-19患者中不同Ct（周期阈值）的差异及临床诊断意义。方法：采用四分位数法将2023年1月1日至5月30日在我院确诊的新冠肺炎患者2836例分为高Ct值组（34.21 ~ 40.00）、中Ct值组（26.51 ~ 34.21）和低Ct值组（0.00 ~ 26.51），阴性组（对照组）。结果：中间Ct组临床指标与对照组比较差异有统计学意义；然而，中高Ct组之间没有显著差异。在高Ct组中，与对照组相比，白蛋白和LDH有显著差异。低Ct组与高Ct组在年龄和LYM%方面有显著差异。此外，低Ct组与中Ct组的年龄有显著差异。尽管如此，在低Ct组和对照组之间未检测到LDH的显著变化。结论：59岁以上人群的病毒载量更高，对COVID-19感染的易感性也更高。白蛋白和LYM%是预防这种疾病的保护因子。年龄、白蛋白和LYM%对区分低Ct组和其他组的个体具有良好的预测价值。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.