Determination of Mineral Element Concentrations in Plasma Samples and Their Correlation to HIV/AIDS

IF 1.8 3区化学 Q4 BIOCHEMICAL RESEARCH METHODS

Rapid Communications in Mass Spectrometry Pub Date : 2025-05-04 DOI:10.1002/rcm.10060

Long-Hua Zhou, Chang-Hua Feng, Xin-Chen Lin, Wei-Hua Huang, Yue Wu, Yong-Jiu Jin, Yang-Yun Zheng, Shuang-Li Guo, Xiang Xia, Wei-Hua Wang, Xiao-Tong Qi, Hui Li

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引用次数: 0

Abstract

Rationale

The main purpose of this study was to contribute to the development of new strategies for prevention and management, ultimately improving the diagnosis, treatment, and overall well-being of affected individuals and communities.

Methods

Plasma samples were collected from 120 HIV-positive individuals and 120 healthy controls. The concentrations of the elements were determined by ICP-MS and ICP-OES. Statistical analysis was performed with the Kolmogorov–Smirnov normality test, the Mann–Whitney U test and the Spearman's rank correlation test.

Results

The study found that HIV/AIDS patients had lower concentrations of Na, Mg, Ca, Fe, Zn, Se, Rb, and Sr compared to the healthy group (p = 0.000 < 0.05). The concentration of I was also lower in HIV/AIDS patients (p = 0.025 < 0.05). However, there was no significant difference in Cu concentrations between the two groups (p = 0.810 > 0.05). HIV/AIDS patients had higher concentrations of Ba (p = 0.000 < 0.05). Significant positive correlations were observed between several element pairs in HIV/AIDS patients, including Na-Ca, Na-Se, Mg-Ca, Mg-Zn, Mg-Sr, Ca-Zn, Ca-Se, Ca-Sr, Fe-Rb, and Sr-Ba at level 0.01, and Na-Zn, Mg-Rb, Mg-Ba, Ca-Ba, and Fe-I at level 0.05. Negative correlations were found between Na-I, Ca-I, Fe-Cu, and Cu-Rb concentrations in HIV/AIDS patients.

Conclusions

In summary, by identifying and addressing imbalances or deficiencies in mineral elements, healthcare providers can optimize patient care and support better health outcomes. This research may lead to the development of interventions targeting mineral imbalances and optimizing immune function in individuals with HIV/AIDS.

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血浆样品中矿质元素浓度的测定及其与HIV/AIDS的相关性

本研究的主要目的是促进新的预防和管理策略的发展，最终改善受影响个人和社区的诊断、治疗和整体福祉。方法采集120例hiv阳性者和120例健康对照者的血浆标本。采用ICP-MS和ICP-OES测定各元素的浓度。统计学分析采用Kolmogorov-Smirnov正态性检验、Mann-Whitney U检验和Spearman秩相关检验。结果HIV/AIDS患者体内Na、Mg、Ca、Fe、Zn、Se、Rb、Sr的浓度低于健康组（p = 0.000 < 0.05）。HIV/AIDS患者I的浓度也较低（p = 0.025 < 0.05）。两组间铜浓度差异无统计学意义（p = 0.810 > 0.05）。HIV/AIDS患者Ba浓度较高（p = 0.000 < 0.05）。HIV/AIDS患者体内Na-Ca、Na-Se、Mg-Ca、Mg-Zn、Mg-Sr、Ca-Zn、Ca-Se、Ca-Sr、Fe-Rb、Sr-Ba元素对在0.01水平上呈显著正相关，Na-Zn、Mg-Rb、Mg-Ba、Ca-Ba、Fe-I在0.05水平上呈显著正相关。HIV/AIDS患者Na-I、Ca-I、Fe-Cu和Cu-Rb浓度呈负相关。总之，通过识别和解决矿物质元素失衡或缺乏，医疗保健提供者可以优化患者护理并支持更好的健康结果。这项研究可能会导致针对艾滋病毒/艾滋病患者矿物质失衡和优化免疫功能的干预措施的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Rapid Communications in Mass Spectrometry 化学-分析化学

CiteScore

4.10

自引率

5.00%

发文量

219

审稿时长

2.6 months

期刊介绍： Rapid Communications in Mass Spectrometry is a journal whose aim is the rapid publication of original research results and ideas on all aspects of the science of gas-phase ions; it covers all the associated scientific disciplines. There is no formal limit on paper length ("rapid" is not synonymous with "brief"), but papers should be of a length that is commensurate with the importance and complexity of the results being reported. Contributions may be theoretical or practical in nature; they may deal with methods, techniques and applications, or with the interpretation of results; they may cover any area in science that depends directly on measurements made upon gaseous ions or that is associated with such measurements.