Exploring virtual reality as an anxiety-inducing paradigm: Multimodal insights from subjective, behavioral and neurophysiological measures

Abstract

Anxiety results from the complex interplay between innate defensive responses to perceived threats and higher-order cognitive processes, mediated by specialized circuits in the human neocortex. Traditional methods of anxiety induction often fail to replicate the inherent unpredictability of threats or maintain ecological validity, thereby limiting their ability to fully elucidate the underlying mechanisms of anxiety. To overcome these limitations, this study aimed to explore the effectiveness of virtual reality (VR) as an innovative anxiety-inducing tool. By further using its ability to simulate real world scenes, the neural activities inducing anxiety in VR scenes were studied. VR is used to induce anxiety through customized scenarios, while a range of data, including subjective self-reports, objective performance measures, eye movement data, and EEG signals, are collected. The findings indicate that VR is efficacious in induced anxiety, which manifests through the arousal of anxious emotions, alterations in cognitive processes, and distinct neurophysiological patterns, particularly increased theta and alpha activity in the frontal and parietal regions. This research reinforces the ecological validity of VR as a research tool, contributing to a deeper understanding of the neurophysiological basis of anxiety and providing a more nuanced framework for both anxiety research and interventions in real-world contexts.