A cyanine-based probe for sensitive and selective detection of mustard gas simulant CEES

IF 4.3 2区化学 Q1 SPECTROSCOPY

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Pub Date : 2025-05-01 DOI:10.1016/j.saa.2025.126318

Ruyu Yan, Liming Hu, Shanyan Mo

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Abstract

A novel cyanine dye-based probe, Cy3CS, was developed and evaluated for the detection of 2-chloroethyl ethyl sulfide (CEES), a simulant for sulfur mustard which is a notorious chemical warfare agent. The probe demonstrated a substantial (as high as 106-fold) fluorescence enhancement upon reaction with CEES even at low concentrations (0.1–1 mM and 0–100 μM). The detection displayed excellent linear correlation between fluorescence intensity and CEES concentration with high R² values (0.9954 and 0.9993 for 0.1–1 mM and 0–100 μM, respectively) and low detection limit (0.44 μM). Meanwhile, the detection does not involve base or other additives, which could simply the detection procedure. The selectivity experiments revealed that the probe responded exclusively to CEES among a range of potential interferents, proving the superior specificity. This selectivity is crucial for accurate detection in complex environments, such as soil samples, which were effectively analyzed using our probe. Thus, the Cy3CS probe offers a significant advancement in the detection of chemical warfare agent’s simulant, with performance metrics that include excellent sensitivity, selectivity, and simplicity of use, establishing it as a promising tool for environmental monitoring and public health safety.

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用于芥子气模拟物CEES敏感和选择性检测的花青碱探针

开发了一种新型的基于菁染料的探针Cy3CS，用于检测2-氯乙基乙基硫化物（CEES），这是一种臭名昭著的化学战剂硫芥的模拟物。即使在低浓度（0.1-1 mM和0-100 μM）下，探针与CEES反应后也显示出大量（高达106倍）的荧光增强。荧光强度与CEES浓度呈良好的线性相关，在0.1-1 mM和0-100 μM范围内R2值高（分别为0.9954和0.9993），检出限低（0.44 μM）。同时，检测不涉及碱或其他添加剂，可简化检测程序。选择性实验表明，该探针在一系列潜在干扰中仅对CEES作出反应，证明了优越的特异性。这种选择性对于在复杂环境中进行准确检测至关重要，例如土壤样品，使用我们的探针可以有效分析土壤样品。因此，Cy3CS探针在检测化学战剂模拟物方面取得了重大进展，其性能指标包括出色的灵敏度、选择性和使用简单性，使其成为环境监测和公共卫生安全的有前途的工具。

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来源期刊

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 物理-光谱学

CiteScore

8.40

自引率

11.40%

发文量

1364

审稿时长

40 days

期刊介绍： Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (SAA) is an interdisciplinary journal which spans from basic to applied aspects of optical spectroscopy in chemistry, medicine, biology, and materials science. The journal publishes original scientific papers that feature high-quality spectroscopic data and analysis. From the broad range of optical spectroscopies, the emphasis is on electronic, vibrational or rotational spectra of molecules, rather than on spectroscopy based on magnetic moments. Criteria for publication in SAA are novelty, uniqueness, and outstanding quality. Routine applications of spectroscopic techniques and computational methods are not appropriate. Topics of particular interest of Spectrochimica Acta Part A include, but are not limited to: Spectroscopy and dynamics of bioanalytical, biomedical, environmental, and atmospheric sciences, Novel experimental techniques or instrumentation for molecular spectroscopy, Novel theoretical and computational methods, Novel applications in photochemistry and photobiology, Novel interpretational approaches as well as advances in data analysis based on electronic or vibrational spectroscopy.