Ti3C2Tx@Pt nanocomposite based colorimetric and electrochemical dual-mode platform for glucose detection

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research Pub Date : 2025-05-02 DOI:10.1016/j.sbsr.2025.100800

Xuming Sun , Mingyan Zhang , Jinlong Chang , Linyan Xie , Qiongqiong Ren , Wenshuai Jiang , Zhen Jin , Shiqi Pan , Xiuli Yang , Wu Ren

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引用次数: 0

Abstract

Glucose is the main source of energy in cellular metabolism and is essential for normal cellular function and growth. Abnormal glucose levels can lead to significant health issues, highlighting the importance of developing efficient, accessible, and precise glucose detection platform. Here, the Ti₃C₂T_x@Pt nanocomposites were developed with uniformly dispersed Pt nanoparticles using a simple self-reduction method, effectively addressing the tendency of pure metal nanoparticles to aggregate. The Ti₃C₂T_x@Pt nanocomposite demonstrated excellent peroxidase like activity and electrocatalytic property, enabling the development of a dual-mode detection platform for glucose that integrated both colorimetric and electrochemical sensing. The colorimetric biosensor demonstrated a linear detection range of 0.5–10 mM with a limit of detection (LOD) 1.37 μM, while the electrochemical biosensor exhibited a linear range of 0.01–11.7 mM with the detection limit of 7.4 μM. This dual-mode platform offered a simple, sensitive, and visualized approach for glucose detection, with broad potential for application in biomedical and clinical diagnostics.

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Ti3C2Tx@Pt基于纳米复合材料的葡萄糖比色电化学双模检测平台

葡萄糖是细胞代谢的主要能量来源，对正常的细胞功能和生长至关重要。血糖水平异常会导致严重的健康问题，因此开发高效、方便、精确的血糖检测平台的重要性凸显出来。本文采用简单的自还原方法制备了均匀分散的Pt纳米粒子Ti3C2Tx@Pt纳米复合材料，有效地解决了纯金属纳米粒子聚集的趋势。Ti3C2Tx@Pt纳米复合材料表现出优异的过氧化物酶样活性和电催化性能，从而开发了一种集比色和电化学传感于一体的葡萄糖双模式检测平台。比色生物传感器的线性检测范围为0.5 ~ 10 mM，检出限为1.37 μM；电化学生物传感器的线性检测范围为0.01 ~ 11.7 mM，检出限为7.4 μM。这种双模平台为葡萄糖检测提供了一种简单、灵敏和可视化的方法，在生物医学和临床诊断中具有广泛的应用潜力。

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来源期刊

Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering

CiteScore

10.70

自引率

3.80%

发文量

审稿时长

87 days

期刊介绍： Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.