Superimposed Effect of Intramolecular Modular Assembling and Silver Coordination to Amplify Superoxide Anion Radical for Antitumor and Antibacterial Photodynamic therapy

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2025-04-16 DOI:10.1021/acsmaterialslett.5c0038110.1021/acsmaterialslett.5c00381

Siwen Wei, Haoran Hou, Yingnan Wu, Wenlong Chen, Gaobo Hong, Dapeng Liu*, Meng Zhou* and Fengling Song*,

引用次数: 0

Abstract

Photodynamic therapy (PDT) calls for highly efficient photosensitizers with a Type I mechanism to overcome the limitation of the hypoxic microenvironment, which exists in both tumor tissues and bacterial infection sites. However, the rational design of Type I PDT photosensitizers is still a challenging goal. Herein, a dyad photosensitizer is developed based on an intramolecular modular assembling strategy to produce superoxide anion radical via a Type I mechanism. Further, the superoxide anion radical amplification is superimposed by silver coordination. In vitro and in vivo antitumor and antibacterial PDT experiments demonstrated the superimposed effect on superoxide anion radical amplification. This work opens a window to rationally design Type I PDT photosensitizers.

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分子内模块组装和银配位增强超氧阴离子自由基的叠加效应在抗肿瘤和抗菌光动力治疗中的应用

光动力疗法（PDT）需要具有I型机制的高效光敏剂来克服存在于肿瘤组织和细菌感染部位的缺氧微环境的限制。然而，合理设计I型PDT光敏剂仍然是一个具有挑战性的目标。本文开发了一种基于分子内模块化组装策略的二元光敏剂，通过I型机制产生超氧阴离子自由基。此外，超氧阴离子自由基扩增被银配位叠加。体外和体内抗肿瘤和抗菌实验表明，PDT对超氧阴离子自由基扩增有叠加作用。本研究为合理设计I型PDT光敏剂打开了一扇窗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.