Clinical Trial: Effect of a 28-Day Low FODMAP Diet on Gastrointestinal Symptoms Associated With Endometriosis (EndoFOD)—A Randomised, Controlled Crossover Feeding Study

IF 6.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Alimentary Pharmacology & Therapeutics Pub Date : 2025-05-04 DOI:10.1111/apt.70161

Jane E. Varney, Daniel So, Peter R. Gibson, Dakota Rhys-Jones, Yuet Sang Jimmy Lee, Jane Fisher, Judith S. Moore, Roni Ratner, Mark Morrison, Rebecca E. Burgell, Jane G. Muir

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引用次数: 0

Abstract

Background

Gastrointestinal symptoms affect most women with endometriosis, but therapeutic interventions are poorly defined.

Aims

To compare the effects of a 28-day low fermentable oligo-, di- and mono-saccharides and polyols (FODMAP) or control diet on gastrointestinal symptom severity in individuals with endometriosis and poorly controlled gastrointestinal symptoms.

Method

In this single-blinded randomised, controlled cross-over feeding trial, we randomised women aged ≥ 18 years to 28 days of either a low FODMAP (< 5 g/day FODMAPs) or control diet (20 g/day FODMAPs), both modelled on Australian Dietary Guidelines, before a ≥ 28-day washout and crossover to the alternate diet. The primary outcome was the proportion of responders defined according to the response in overall gastrointestinal symptoms on a 100-mm visual analogue scale. Secondary outcomes included gastrointestinal symptoms, quality of life and psychological status.

Results

Of 35 women randomised (mean age 31; 95% confidence interval 29, 33 years), 21 (60%) responded to the low FODMAP diet compared with 9 (26%) to the control diet (p = 0.008). In the 4th week of the dietary intervention, overall symptom scores were 35 (21, 42) mm on the low FODMAP diet and 58 (55, 65) mm on the control diet (p < 0.001). Abdominal pain, bloating, stool form and quality of life for both gastrointestinal and endometriosis-associated scales were significantly better for the low FODMAP diet compared with the control diet, but not overall for perceived stress, anxiety or depression.

Conclusions

The low FODMAP diet ameliorates gastrointestinal symptoms related to endometriosis and improves quality of life. Confirmation of these findings in a real-world setting is required.

Trial Registration

The trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12621000153819).

查看原文本刊更多论文

临床试验：28天低FODMAP饮食对子宫内膜异位症（EndoFOD）相关胃肠道症状的影响——一项随机、对照交叉喂养研究

背景：胃肠道症状影响大多数子宫内膜异位症患者，但治疗干预措施尚不明确。目的比较28天低发酵寡糖、二糖和单糖和多元醇（FODMAP）或对照饮食对子宫内膜异位症患者胃肠道症状严重程度的影响。方法在这项单盲、随机、对照交叉喂养试验中，我们将年龄≥18岁至28天的女性随机分为低FODMAP组(<；5 g/天FODMAPs)或对照饮食（20 g/天FODMAPs），均以澳大利亚膳食指南为模型，然后进行≥28天的洗脱期并切换到替代饮食。主要结局是根据在100‐mm视觉模拟量表上对整体胃肠道症状的反应来定义应答者的比例。次要结局包括胃肠道症状、生活质量和心理状态。结果35名随机女性(平均年龄31岁；95%可信区间为29,33年)，21例（60%）对低FODMAP饮食有反应，9例（26%）对对照饮食有反应（p = 0.008）。在饮食干预的第4周，低FODMAP饮食组的总症状评分为35 (21,42)mm，对照组的总症状评分为58 (55,65)mm (p <；0.001)。与对照饮食相比，低FODMAP饮食组在胃肠道和子宫内膜异位症相关量表上的腹痛、腹胀、大便形态和生活质量明显更好，但在感知压力、焦虑或抑郁方面总体上没有改善。结论低FODMAP饮食可改善子宫内膜异位症相关胃肠道症状，提高生活质量。这些发现需要在现实世界中得到证实。试验注册该试验已在澳大利亚新西兰临床试验注册中心注册（ACTRN12621000153819）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alimentary Pharmacology & Therapeutics 医学-胃肠肝病学

CiteScore

15.60

自引率

7.90%

发文量

527

审稿时长

3-6 weeks

期刊介绍： Alimentary Pharmacology & Therapeutics is a global pharmacology journal focused on the impact of drugs on the human gastrointestinal and hepato-biliary systems. It covers a diverse range of topics, often with immediate clinical relevance to its readership.