One-step synthesis of PtRhMo/Rh nanozymes for mitochondrial damage-mediated photothermal/enzymatic therapy

IF 6.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Science China Materials Pub Date : 2025-04-08 DOI:10.1007/s40843-024-3300-6

Danyang Li (, ), Enna Ha (, ), Yaoyao Zhu (, ), Shuqing He (, ), Shaolong Kuang (, ), Junqing Hu (, )

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引用次数: 0

Abstract

Photothermal therapy (PTT) circumvents the constraints of conventional treatments and has manifested substantial potential for clinical applications. Nevertheless, the up-regulation of heat shock proteins (HSP) and mitochondria-encoded genes within tumor cells endows them with a high level of heat resistance, thereby limiting the ultimate efficacy of PTT. Herein, PtRhMo/Rh multi-metal-based nanozymes were designed by a one-step method for PTT and cascade enzymatic therapy. The PtRhMo/Rh nanozymes are capable of combining multiple enzymatic activities (catalase, oxidase, glutathione peroxidase, NADH oxidase and peroxidase) for reactive oxygen radical boosting. With the help of the near-infrared laser, PtRhMo/Rh nanozymes can not only kill tumor cells directly, but also down-regulate HSP70 level and destroy the mitochondrial to weaken the heat-resistant ability of tumor cells, further enhancing the effect of PTT. Overall, our work highlights a synergistic strategy for enzymatic therapy and enhanced PTT.

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一步合成用于线粒体损伤介导的光热/酶治疗的PtRhMo/Rh纳米酶

光热疗法（PTT）克服了传统疗法的局限性，在临床应用中表现出巨大的潜力。然而，肿瘤细胞内热休克蛋白（HSP）和线粒体编码基因的上调使其具有高水平的耐热性，从而限制了PTT的最终疗效。本文采用一步法设计了PtRhMo/Rh多金属基纳米酶，用于PTT和级联酶治疗。PtRhMo/Rh纳米酶能够结合多种酶活性（过氧化氢酶、氧化酶、谷胱甘肽过氧化物酶、NADH氧化酶和过氧化物酶）来促进活性氧自由基。在近红外激光的帮助下，PtRhMo/Rh纳米酶不仅可以直接杀死肿瘤细胞，还可以下调HSP70水平，破坏线粒体，削弱肿瘤细胞的耐热能力，进一步增强PTT的效果。总的来说，我们的工作强调了酶治疗和增强PTT的协同策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.